宫颈髓外浆细胞瘤临床病理分析并文献复习  

Clinicopathologic Analysis of Extramedullary Plasmacytoma in Cervix and a Literature Review

作　　者：沈小英[1] 亓岽东[2] 武鑫瑞[1] 王慧芳[1] 许春伟[3] 吴继华[1] 

机构地区：[1]解放军306医院病理科,北京100101 [2]大连大学附属中山医院肿瘤科,辽宁大连116001 [3]军事医学科学院附属医院病理科,北京100071

出　　处：《解放军医药杂志》2016年第9期65-68,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨宫颈髓外浆细胞瘤的临床病理特点及鉴别诊断。方法对1例宫颈髓外浆细胞瘤的临床表现、影像学、病理组织学变化、免疫表型及基因检测进行分析,并结合相关文献进行讨论。结果肿瘤细胞弥漫分布,主要由成熟浆细胞构成,分裂象可见。免疫组织化学染色显示肿瘤细胞CD79α、CD38、CD138和Kappa均阳性,Lambda、MUM-1、CD3、CD5、CD20和EBV均阴性。WT1 mRNA和PRAME mRNA水平分别为0.073%和0.080%;IGH基因继裂重组阳性。结论发生于宫颈的髓外浆细胞瘤是一种非常罕见的肿瘤,其临床表现及影像学均无特征性,明确诊断主要依靠病理组织学特征、免疫表型及基因分析。Objective To investigate clinicopathological characteristics and differential diagnosis of extramedul-lary plasmacytoma （ EMP） in cervix. Methods Clinical manifestation, medical imaging, histopathological changes, im-munophenotype and gene test of 1 EMP patient in cervix were analyzed, and related literature review was also performed. Results Diffuse distribution of tumor cells mainly made up of mature plasma cells with visible karyokinesis. Immunohis-tochemically staining showed that CD79α, CD38, CD138 and Kappa tumor cells were positive, and Lambda, MUM-1, CD3, CD5, CD20 and EBV were negative. levels of WT1 mRNA and PRAME mRNA were 0. 073% and 0. 080% re-spectively, and breakage and recombinant of IGH gene was positive. Conclusion EMP in cervix is a rare tumor, and its clinical feature and medical imaging are atypical. Its diagnosis mainly relies on clinicopathological characteristics, immu-nophenotype and gene analysis.

关 键 词：浆细胞瘤 病理学 临床 免疫组织化学 诊断 鉴别 

分 类 号：R730.263[医药卫生—肿瘤]