肠易激综合征动物模型的研究进展  

Research progress on animal model of irritable bowel syndrome

作　　者：任杰[1] 陆敏[2] 

机构地区：[1]南京中医药大学第三临床医学院,江苏南京210046 [2]南京中医药大学附属中西医结合医院消化科,江苏南京210028

出　　处：《中国医药导报》2016年第27期47-50,共4页China Medical Herald

基　　金：江苏省科技项目(BK20161608);江苏省中医药科技项目(YB2015039);中国中医科学院江苏分院项目(JSBN1305)

摘　　要：肠易激综合征(IBS)是一种功能性肠病,其病因及发病机制尚未完全阐明。目前临床上的主要治疗原则仍是对症治疗。关于IBS动物模型的研究有很多,最常用实验动物是大鼠与小鼠。模型构建方法较多,有物理化学刺激、心理应激、药物致泻、病原体感染、复合方法及其他方法等。观测指标包括一般情况、肠道敏感性测试、肠道转运功能、病理学检查、相关脑肠肽的检测等。现在的动物模型大多仅从病理生理机制中的某一方面着手,而IBS的发病机制复杂,诱发因素个体化、多样,因此目前的动物模型均具有不同程度的局限性,还需进一步研究。本文拟对IBS动物模型研究进展作一综述。Irritable bowel syndrome （IBS） is a kind of functional bowel disease, and its etiology and pathogenesis has not been fully elucidated. At present, the main treatment principle is still symptomatic therapy. There are a lot of re- searches on IBS animal model, in which rats and mice are the most commonly animals used. Model construction meth- ods are so many, such as physical and chemical stimulation, psychological stress, drug induced diarrhea, pathogen in- fection, compound method and others. The observation indexes included general situation, intestinal sensitivity test, in- testinal transit function, pathological examination, and the detection of related brain gut peptide. Animal model now proceed only from a certain aspect of pathophysiological mechanism, however the pathogenesis of IBS is complex, in- ducing factors individual and diversified. So current animal model has limitations to some extent, and need further study. This paper aims to review the research progress on animal model of IBS.

关 键 词：肠易激综合征 动物模型 建模方法 观测指标 

分 类 号：R574[医药卫生—消化系统]