米邦塔仙人掌果胶对小鼠慢性不可预知温和应激所致抑郁样症状的改善作用  

Effects of Milpa Alta Cactus Pectin on Depression-like Symptoms Induced by Chronic Unpredictable Mild Stress in Mice

作　　者：张玉宝 李祖铭 余玲 罗攀[2] 湛进进[2] 郭莲军[2] 

机构地区：[1]湖北省宜昌市夷陵区妇幼保健院,湖北宜昌443100 [2]华中科技大学同济医学院药理教研室,武汉430030

出　　处：《神经损伤与功能重建》2016年第5期385-387,共3页Neural Injury and Functional Reconstruction

基　　金：中央高校基本科研业务费专项资金资助(No.2011TS073);国家重大创新平台重点资助新药研发项目(No.2009ZX09301-014)

摘　　要：目的:研究米邦塔仙人掌果胶(milpa alta cactus pectin,MCP)对小鼠慢性不可预知温和应激(CUMS)后体重和糖水偏好的影响。方法:健康雄性昆明种小鼠60只随机分为5组:正常对照组、CUMS组、MCP低剂量组(50 mg/kg)、MCP中剂量组(100 mg/kg)、MCP高剂量组(200 mg/kg),各10只。采用11种应激因子,建立CUMS模型,给予小鼠应激6周。通过测量糖水摄入和小鼠体重变化率,评价MCP对抑郁样症状的改善作用。结果:CUMS组小鼠体重增长率、糖水摄入量都显著低于正常对照组(P<0.05);与CUMS组比较,MCP中、高剂量组小鼠体重变化率、糖水摄入量明显增加(P<0.05)。结论:MCP对CUMS所致抑郁样症状具有一定的改善作用。Objective： To investigate the effect of milpa alta cactus pectin （MCP） on body weight and the su- crose preference in mice suffered from a chronic unpredictable mild stress （CUMS）. Methods： Sixty male Kun- ming mice were randomly divided into 5 groups： Control, CUMS, CUMS＋MCP 50 mg/kg, CUMS ＋MCP 100 mg/kg, CUMS ＋MCP 200 mg/kg,10 in each group. Mice were exposed to CUMS for 6 weeks. During every week of CUMS, the weight and sucrose preference of mice were measured. Results： The weight increasing rate and the sucrose preference of CUMS mice were significant lower compared with the control group （P〈0.05）. While treated with MCP at dose of 100 mg/kg and 200 mg/kg can significantly increase the weight increasing rate and sucrose preference compared with the CUMS group （P〈0.05）. Conclusion： MCP can ameliorate the de- pression-like symptoms induced by chronic unpredictable mild stress in mice.

关 键 词：米邦塔仙人掌果胶 慢性不可预知温和应激 糖水偏好性 小鼠 

分 类 号：R741[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]