早期应用高渗盐水对急性颅脑损伤后应激性高血糖的影响  

Effects of Hypertonic Saline on Stress Hyperglycemia in Patients with Traumatic Craniocerebral Injury

作　　者：王建祥[1] 周锐[1] 竹梦[1] 沈俊[1] 范渊[1] 

机构地区：[1]华中科技大学同济医学院附属普爱医院综合外科,武汉430000

出　　处：《神经损伤与功能重建》2016年第5期414-415,共2页Neural Injury and Functional Reconstruction

基　　金：基金项目2011年武汉市卫生与计划生育委员会(No.WX11C19)

摘　　要：目的:探讨早期应用高渗盐水对急性颅脑损伤后应激性高血糖的影响。方法:急性重型颅脑损伤患者146例,随机分为甘露醇组和高渗盐水组各73例,分别给予甘露醇或高渗盐水治疗,测定2组入院后24、48、72、96 h的血糖值、HOMA-IR值及NCU住院时间。结果:与甘露醇组相比,高渗盐水组入院后72、96 h的血糖值、HOMA-IR值明显降低(P<0.05),NCU住院时间明显缩短(P<0.05)。结论:早期应用高渗盐水治疗急性颅脑损伤患者可降低应激性高血糖、缩短NCU住院时间。Objective： To investigate the effect of hypertonic saline on stress hyperglycemia in patients with traumatic craniocerebral injury. Methods： Total 146 patients with traumatic craniocerebral injury were randomly divided into mannitol group and hypertonic saline group, and given mannitol or hypertonic saline therapy respectively. The blood glucose levels, HOMA-IR levels at 24, 48, 72, 96 h after admission and the duration of stay in NCU ward were recorded. Results： The blood glucose levels and HOMA-IR levels in the hypertonic saline group were significantly lower than those in the mannitol group at 72, 96 h （P〈0.05）. The duration of stay in NCU in the hypertonic saline group were significantly shorter than those in the mannitol group （P〈0.05）. Conclusion： Early hypertonic saline therapy on patients with traumatic craniocerebral injury can effectively decrease the stress hyperglycemia and shorten the stay in the NCU.

关 键 词：高渗盐水 颅脑损伤 应激性高血糖 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]