可见光下曙红Y催化的吲哚酮类化合物的合成  

Synthesis of Oxindoles by Eosin Y Catalyzed under Visible Light

作　　者：田文艳[1,2] 徐松[1,2,3] 梁中卫 孙德立[1,2] 张荣华[1,2] 

机构地区：[1]同济大学化学系,上海200092 [2]上海市化学评估与可持续发展重点实验室,上海200092 [3]嘉兴学院化学与制药工程学院,嘉兴31400

出　　处：《有机化学》2016年第9期2121-2129,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20972113/B020502)资助项目~~

摘　　要：报道了在可见光下N-芳基丙烯酰胺与溴丙二酸二乙酯的串联环化反应来合成一系列包含丙二酰基的吲哚酮类化合物.反应用便宜、易处理、对环境无污染的曙红Y作光催化剂在室温下反应获得较好收率的产物.为吲哚酮类化合物的合成提供了一种简便经济的方法.A novel visible-light-introduced reaction for the construction of oxindole derivatives via tandem radical cyclization of N-aryl acrylamides with diethyl bromomalonate has been developed. The reaction has been achieved in high yield under mild conditions by using Eosin Y as photocatalyst, which is cheap, easy to handle and environmentally friendly. It might provide a promising protocol for the synthesis of oxindole derivatives.

关 键 词：曙红Y 可见光催化 吲哚酮 自由基环化 

分 类 号：O626[理学—有机化学]