聚酰胺类多肽二级结构模拟物的结构设计与性质分析  

The Structural Designs and Property Analysis of Polyamide Based Structures as Peptide Secondary Structure Mimics

作　　者：王志鹏[1,2] 田长麟[1] 郑基深[1] 

机构地区：[1]中国科学技术大学生命科学学院,合肥230026 [2]美国德克萨斯农工大学化学系,德州77840

出　　处：《化学进展》2016年第9期1328-1340,共13页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21402206);安徽省自然科学基金(No.1508085QB30);北京分子科学国家实验室资助(No.20140124)~~

摘　　要：多肽与蛋白质具有结构支持、酶促催化、蛋白-蛋白相互作用等一系列功能。其中,二级结构作为少数氨基酸参与的相对局域性的结构,是一切高级结构的基础。为了模拟天然多肽的结构与功能,人们成功设计并合成了多种非天然的寡聚物结构。这些拟肽或类肽结构能有效地模拟以α-螺旋、转角为主体的多肽二级结构。二级结构模拟物具有重要的理论意义,并被进一步用于蛋白-蛋白相互作用的抑制剂研究与新药设计中。本文从分析多肽的二级结构特征入手,分类阐述了目前的各类多肽二级结构模拟物,并重点分析了最为主要的基于酰胺键型的模拟物的设计与结构多样性。同时,本文提出一系列形象化的命名手段进行分类,如χ肽、ζ/ξ-肽及ζ-ξ-肽等。The peptides and proteins lay the foundation of diverse functions including structural supporting,enzymatic catalysis,protein-protein interactions etc. Specifically,secondary structures are essential elements for any possible higher structures,as rather localized motifs w ith limited amino acid residues involved. Now adays,different non-natural oligomers have been developed for the peptide structural and functional mimicking,such asα-helix and turns. Protein secondary structure mimics are a group of organic compounds with theoretical importance,w hich can be further applied to protein-protein inhibitor study as w ell as drug design. This manuscript starts w ith the property analysis of typical protein secondary structures,follow ed by the introduction of current peptide secondary structure mimics. These foldamers are divided into three main groups,and the design principles as w ell as the structural diversity of oligo / poly-amide based peptide secondary structure mimics are emphasized. Additionally,the draft provides several visualizable nomenclature,including χ-peptides,ζ / ξ-peptides,and ζ-ξ-peptides.

关 键 词：多肽 二级结构 拟肽 二级结构模拟物 聚酰胺 

分 类 号：O641.3[理学—物理化学] O641.4[理学—化学]