帕金森病伴认知障碍患者血尿酸变化及相关因素分析  被引量:3

Study on uric acid and the related factors associated with cognition impairment in the patients with Parkinson's disease

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作  者:叶心国[1] 徐峻峰[2] 万汉英[2] 

机构地区:[1]武汉大学人民医院神经内科,430060 [2]鄂州市中心医院神经内科

出  处:《卒中与神经疾病》2016年第4期267-270,共4页Stroke and Nervous Diseases

摘  要:目的探讨帕金森病患者认知功能和血尿酸水平的关系并对认知功能相关因素进行分析。方法入选PD患者78例和年龄、性别相匹配的40例健康对照组,记录PD患者的性别、年龄、病程、受教育年限、Hoehn&Yahr(H-Y)分级,采用蒙特利尔认知评估量表(Mo CA)对所有研究对象认知功能进行评估,对血尿酸、尿微量白蛋白水平进行检测。结果 PD组血尿酸水平明显低于健康对照组[(258.16±57.58)μmol/L比(330.23±52.92)μmol/L,P<0.01];早期PD组与中晚期PD组血尿酸水平无明显差异(P>0.05);但合并轻度认知功能障碍(MCI)的PD组血尿酸水平低于无MCI的PD组[(235.16±68.36)μmol/L比(272.58±59.69)μmol/L,P<0.01];各亚组间及各亚组与对照组比较尿微量白蛋白水平无明显差异(P>0.05);PD患者Mo CA评分与受教育年限(β=0.552,P<0.01)、血清尿酸水平(β=0.483,P<0.01)呈正相关,与病程(β=-0.469,P<0.05)、H-Y分级(β=-0.324,P<0.05)呈负相关。结论尿酸水平的改变可能参与了PD患者的发病机制;血尿酸水平下降可能是PD合并认知障碍的一个重要危险因素,对血尿酸水平进行适当干预可能有助于提高帕金森病患者的生活质量。Objective To explore the relation of cognition and uric acid in Parkinson's disease and analyze the related factors of cognition. Methods 78 PD patients were enrolled, and 40 age- and gendermatched healthy subjects were used as controls. The information including gender, age, illness duration, years of education and Hoehn & Yahr (H-Y)stage were recorded. Cognitive function of all the patients with PD and the controls were measured by using Montreal Cognitive Assessment (MoCA) scale. The levels of serum uric acid and urinary microalbumin were measured. Then we compared and analyzed the results. Results Serum levels of uric acid in PD group were significantly lower than the control group [(258. 16 ± 57. 58)μmol/L 比(330. 23 ±52. 92)μmol/L,P〈0. 01]. Serum levels of uric acid had no differences between early PD group and middlelate PD group of patients (P〉0. 05). Serum levels of uric acid in PD group with mild cognitive impairment (MCI) were obviously lower than PD group without MCI [(235.16± 68. 36)μmol/L 比 (272. 58 ± 59. 69) μmol/L,P〈0. 01]. There were no significant differences in the level of urinary microalbumin between each sub group and control group(P》0. 05). In PD patients, MoCA scores were positively correlated with duration of education (β = 0. 552, P〈 0. 01) and serum levels of uric acid (β = 0. 483, P〈 0. 01), and were negatively correlated with illness duration(β = - 0. 469, P〈0. 05) and H-Y stag(β= - 0. 324, P〈0. 05). Conclusion The changes of serum levels of uric acid may be involved in the pathogenesis of patients with PD. The lower levels of uric acid may be one of risk factors in PD patients with cognitive impairment. Appropriate intervention on blood uric acid level may be help to improve PD patients^quality of life.

关 键 词:帕金森病 认知功能障碍 尿酸 尿微量白蛋白 

分 类 号:R742.5[医药卫生—神经病学与精神病学]

 

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