鲁西冀南地区低剂量螺旋CT在肺癌筛查中的应用  

Clinical application of low-dose spiral CT screening for lung cancer in western Shandong and southern Hebei

作　　者：解耀锃[1] 霍晓恺[2] 鲁强[1] 李吉臣[1] 

机构地区：[1]聊城市第二人民医院CT室,山东临清252600 [2]聊城市第二人民医院超声科,山东临清252600

出　　处：《中华胸部外科电子杂志》2016年第3期164-169,共6页CHINESE JOURNAL OF THORACIC SURGERY：Electronic Edition

摘　　要：目的：探讨鲁西冀南地区低剂量螺旋 CT（LDCT）在不同性别和年龄人群中肺癌检出率的差异，为制定更适宜的筛查方案提供依据。方法回顾性分析2015年在聊城市第二人民医院进行LDCT 肺癌筛查的2056例受检者的资料。根据性别、国内肺癌高危人群年龄段，以及实际检出高危人群年龄段三种方法进行分组，比较各组间肺癌检出率的差异。结果2056例受检者中，确诊肺癌22例，其中腺癌20例，鳞癌2例。45～75岁共检出肺癌21例，占总检出人数的95．5％（21／22）。男性组肺癌检出率为0．8％（10／1217），女性组为1．4％（12／839），两组比较差异无统计学意义（χ^2＝1．738， P ＝0．187）。根据国内肺癌高危人群定义中的年龄段分组，高危组（50～75岁）肺癌检出率为1．3％（15／1158），低危组（＜50岁或＞75岁）为0．8％（7／898），两组比较差异无统计学意义（χ^2＝1．271，P ＝0．26）。根据实际检出高危人群的年龄段分组，新高危组（45～75岁）肺癌检出率为1．4％（21／1502），新低危组（＜45岁或＞75岁）为0．2％（1／554），新高危组检出率显著高于新低危组（χ^2＝5．668，P ＝0．017）。结论鲁西冀南地区人群在 LDCT 肺癌筛查中，不仅要关注男性，也要关注女性；且将肺癌筛查高危人群年龄调整为45～75岁更为合适。Objective To investigate the differences in lung cancer detection rates with low-dose spiral CT（LDCT） among people with different genders and ages in western Shandong and southern Hebei,and provide evidence for making better screening programs.Methods The clinical data of 2 056 cases undergoing lung cancer screening with LDCT in Liaocheng Second People＇s Hospital in 2015 were retrospectively analyzed.Patients were divided into groups by gender,by age based on expert consensus of high-risk population of lung cancer and by age according to the actual findings of high-risk population of lung cancer, respectively, and the lung cancer detection rates were compared between groups, respectively.Results Twenty-two of these 2 056 cases were confirmed as lung cancer,among whom 20 were adenocarcinoma and the other 2 were squamous cell carcinoma.Twenty-one（95.5%）cases with lung cancer aged between 45 and 75 years.The lung cancer detection rates of males and females were 0.8%（10/1 217） and 1.4%（12/839）,respectively,and there was no significant difference between them（χ^2 = 1.738,P =0.187）.Based on expert consensus of high-risk population of lung cancer,the lung cancer detection rates of high-risk group（50-75 years old） and low-risk group（〈50 years or 〉75 years） were 1.3%（15/1 158） and 0.8%（7/898）,respectively,and there was no significant difference between them（χ^2 =1.271,P =0.26）.According to the actual findings of high-risk population of lung cancer,the lung cancer detection rates of new high-risk group（45-75 years old） and new low-risk group （〈45 years or 〉 75 years） were 1.4%（21/1 502） and 0.2%（1/554）,respectively,and there were＆amp;nbsp;significant differences between them（χ^2 =5.668,P =0.017）.Conclusions Attention should be paid to lung cancer screening with LDCT both in males and females in western Shandong and southern Hebei, and the age of high-risk population of lung cancer is well to be defined as 45-75 years.

关 键 词：体层摄影术 X线摄影机 肺癌 筛查 低剂量螺旋CT 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]