腹腔镜直肠癌根治术中应用纳米炭示踪剂对免疫及肝肾功能的影响  

Effects of the nano carbon tracer on immunologic and hepatorenal functions in patients with the surgery of laparoscopic colorectal cancer radical prostatectomy

作　　者：田相安 丁元升[1] 杨成菊[1] 孙钦立[1] 

机构地区：[1]临沂市沂水中心医院普外科,山东临沂276400

出　　处：《现代肿瘤医学》2016年第21期3451-3454,共4页Journal of Modern Oncology

基　　金：临沂市医疗卫生科技发展计划项目(编号:201515032)

摘　　要：目的:探讨纳米炭示踪剂在腹腔镜直肠癌根治术中对机体免疫功能及肝肾功能的影响。方法:按照随机化原则将60例直肠癌患者分为纳米炭组和对照组,纳米炭组30例于术前经肛门注射纳米炭混悬注射液,对照组30例不注射纳米炭混悬注射液。两组均由同组手术医师按相同手术原则行腹腔镜辅助下直肠癌根治术。分别测定术前1天和术后第1、3、5、7天肝肾功、CD3^+细胞、CD4^+细胞、CD8^+细胞、CD4^+/CD8^+比值并进行对比。结果:与术前1天相比,术后第1天两组免疫功能指标均不同程度的出现降低,以纳米炭组下降更显著,对照组术后第3天开始回升,至术后第5天基本恢复正常,纳米炭组术后第5天开始回升,至术后第7天恢复基本正常。术后ALT、AST、BUN、Cr均在正常范围,差异无统计学意义(P>0.05)。纳米炭组与对照组相比,免疫功能恢复时间偏长。结论:纳米炭在腹腔镜直肠癌中的应用对机体的免疫功能有一过性抑制作用,对肝肾功无影响。ObjectiveTo study the impact of nano carbon tracer on immunologic and hepatorenal functions in pa-tients with the surgery of laparoscopic colorectal cancer radical prostatectomy. Methods ： By the principal of randomi-zation, 60 patients with colorectal cancer were divided into two groups,30 cases in each. The nano group patients were injected nano carbon suspension injection through anal before the surgery. While the control group patients with no in-tervention. After that two groups were treated by the same principle of the operation. The level of CD3 ＋ , CD4 ＋ ,CD8 ＋ ,CD4＋/CD8＋ ,the hepatorenal function were measured before and 1st, 3rd, 5th,7th after the operation. Re-sults： The immunologic function indicators of two groups were both degraded 24 hours after operation, where as nano group was significantly fallen. The abnormalities of immunologic function indicators started to rise from the 3rd day and returned to normal levels on the 5th day in the control group. While the nano group was elevated from 5th day and restored to normal on the 7th day. The serum AST, ALT, BUN and Cr were all in the normal range（P 〉 0. 05 ）. In nano group,the immune function recovery time was longer compared with the control group. Conclusion： In applica-tion of laparoscopic surgery nano carbon tracer has a transient inhibition to the human immunologic function, it has no effects on liver and kidney function.

关 键 词：纳米炭 腹腔镜 免疫功能 肝肾功能 

分 类 号：R735.37[医药卫生—肿瘤]