慢性结石性胆囊炎与胆囊癌关系的研究进展  

Research progress on the relationship between chronic calculus cholecystitis and gallbladder carcinoma

作　　者：邹荣基 马庆久[2] 

机构地区：[1]西安医学院,陕西西安710068 [2]西安医学院附属西安高新医院普外科,陕西西安710075

出　　处：《中国当代医药》2016年第26期15-18,共4页China Modern Medicine

摘　　要：胆囊癌是胆道系统最常见的恶性肿瘤,其主要的风险因素是由于长时间暴露于胆囊结石。在胆囊上皮细胞损伤-修复反复循环形成的慢性炎症环境下,通过"化生-异型增生-癌"这一过程,促进了胆囊上皮细胞形态学上的受损改变。本文就慢性结石性胆囊炎与胆囊癌的关系进行综述,为胆囊癌的预防、早期诊断、药物治疗提供研究依据。Gallbladder carcinoma is the most common malignant tumor in biliary system.The main risk factors are due to prolonged exposure to gallbladder stones.Under the chronic inflammatory environment enabled by the recurrent cycles of gallbladder epithelium damage-repair,which promotes morphological impairment of gallbladder epithelial cells through the process of ＂metaplasia and dysplasia and cancer＂.In this paper,the relationship between chronic calculus cholecystitis and gallbladder carcinoma is reviewed,which provides the research basis for the prevention,early diagnosis and drug treatment of gallbladder carcinoma.

关 键 词：胆囊结石 慢性结石性胆囊炎 环氧化酶-2 C反应蛋白 肝X受体 胆囊癌 

分 类 号：R575.6[医药卫生—消化系统] R735.8[医药卫生—内科学]