精氨酸联合纳洛酮治疗肝硬化并发肝性脑病的效果分析  

Effect analysis of arginine combined with naloxonein in treatment of liver cirrhosis complicated with hepatic encephalopathy

作　　者：程荷珍[1] 张忠元[1] 

机构地区：[1]武汉科技大学附属天佑医院药剂科,湖北武汉430064

出　　处：《中国当代医药》2016年第26期121-123,共3页China Modern Medicine

摘　　要：目的探讨精氨酸联合纳洛酮治疗肝硬化并发肝性脑病的效果。方法选取2010年4月~2013年3月我院门诊或住院部收治的106例肝硬化并发肝性脑病患者,根据就诊时间的不同将其分为治疗组和对照组,每组53例。对照组给予纳洛酮静脉滴注治疗,治疗组给予精氨酸联合纳洛酮静脉滴注治疗。比较两组患者治疗效果,治疗前后血氨、总胆红素（TBil）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）水平变化情况,不良反应发生情况。结果治疗组治疗后总有效率为90.57%,高于对照组的75.47%,差异有统计学意义（P〈0.01）;治疗后,两组血氨、TBil、ALT、AST水平显著低于治疗前,差异有统计学意义（P〈0.01）;治疗后,治疗组血氨、TBil、ALT、AST水平降低程度优于对照组治疗后（P〈0.01）;两组患者治疗过程中均无明显不良反应发生。结论精氨酸联合纳洛酮治疗肝硬化并发肝性脑病疗效确切。Objective To investigate the effect of arginine combined with naloxone in treatment of hepatic cirrhosis complicated with hepatic encephalopathy therapeutic.Methods 106 cases of liver cirrhosis complicated with hepatic encephalopathy patients in our hospital outpatient or inpatient treatment from April 2010 to March 2013 were divided into two groups according to the different treatment time,53 cases in each group;the control group was given naloxone infusion therapy,the treatment group was given naloxone and arginine infusion for treatment.The effect of two groups before and after treatment,blood ammonia,serum total bilirubin（TBil）,alanine aminotransferase（ALT）,glutamic oxaloacetic transaminase（AST） level changes,the incidence of adverse reaction were compared.Results The total effective rate of treatment group after treatment was 90.57%,significantly higher than 75.47% in control group,and the difference was statistically significant（P〈0.01）;after treatment,blood ammonia,TBil,ALT,AST levels of two groups was significantly lower than that before treatment respectively,with statistical difference（P〈0.01）;blood ammonia,TBil,ALT,AST levels decreased after treatment in treatment group was better than that of control group after treatment（P〈0.01）;the two groups of patients during treatment had no obvious adverse reaction.Conclusion Curative effect of arginine combined with naloxone in treatment of liver cirrhosis complicated with hepatic encephalopathy is definite.

关 键 词：精氨酸 纳洛酮 肝硬化 肝性脑病 

分 类 号：R747.9[医药卫生—神经病学与精神病学]