肝脏生化功能检测在乙肝肝硬化病情评估中的应用价值研究  

Application value of liver biochemical function test in the evaluation of hepatitis B cirrhosis

作　　者：何丹枫[1] 马凌波[1] 

机构地区：[1]广西壮族自治区南溪山医院检验科,广西桂林541002

出　　处：《中国当代医药》2016年第26期143-145,共3页China Modern Medicine

摘　　要：目的探讨肝脏生化功能检测用于乙肝肝硬化（HBC）病情评估的临床价值。方法选择2014年1月~2016年3月在我院接受治疗的52例HBC患者作为观察组,根据Child-Pugh分级标准分级;选取同期52例健康体检人员作为对照组。检测所有受试人员的各项肝脏生化指标,并进行统计比较。结果与对照组比较,观察组血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、总胆红素（TBil）、总胆汁酸（TBA）、直接胆红素（DBil）水平显著增加（P〈0.05）,白蛋白（ALB）、总蛋白（TP）、凝血酶原时间（PT）和白蛋白/球蛋白（A/G）明显下降（P〈0.05）;不同Child-Pugh分级间的各项肝功能指标均差异有统计学意义（P〈0.05）。结论 ALT、AST、ALP、TBil等各项肝功能指标与HBC的病情程度密切相关,可作为HBC诊断及病情判断的重要生化指标。Objective To investigate the clinical value of detection of liver biochemical function in hepatitis B liver cirrhosis（HBC）.Methods From January 2014 to March 2016,52 cases of HBC in our hospital were selected as the observation group according to the Child-Pugh classification criteria for grading.52 cases of healthy persons were selected as the control group.The liver biochemical indexes of all the subjects were tested and compared.Results Compared with the control group,the level of serum ALT,AST,ALP,TBil and TBA and DBil in the observation group significantly increased（P〈0.05）,while ALB,TP and A/G decreased significantly（P〈0.05）.Various liver function indexes of different ChildPugh grades were significantly different（P〈0.05）.Conclusion The liver function indexes,such as ALT,AST,ALP,TBil and so on,are closely related to the severity of HBC,and can be used as an important biochemical index for HBC diagnosis and disease diagnosis.

关 键 词：乙肝肝硬化 肝功能 生化检测 病情评估 

分 类 号：R575.2[医药卫生—消化系统]