MicroRNA-424参与多种疾病发生发展的分子机制研究进展  

Progress in studies of microRNA-424-associated diseases and related mechanism

作　　者：赵海苹[1] 刘萍[2] 罗玉敏[1] 

机构地区：[1]首都医科大学宣武医院脑血管病研究室,北京100053 [2]首都医科大学宣武医院,神经内科,北京100053

出　　处：《中国比较医学杂志》2016年第9期76-82,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金项目(81571280,81201028,30770743)

摘　　要：近20余年大量研究发现miRs靶向mRNA,通过降解mRNA或抑制其翻译,控制细胞增殖、分化、凋亡等多种生理病理过程,参与个体发育和疾病的发生发展。近年研究发现miR-424是血管生成的重要调节因子,参与了多种疾病的发生发展过程,本文对miR-424在感染性疾病、血管性疾病、中枢神经系统疾病及生殖系统疾病等多种疾病中的表达变化、作用及机制进行了综述。MiRs display an important role in a variety of biological,physiological and pathological processes,including cell proliferation,differentiation,apoptosis,individual development,occurrence and progress of diseases.Recent studies have discovered that miR-424 is the significant regulatory factor of angiogenesis,and is involved in many diseases such as infectious diseases,vascular diseases,central nervous system diseases and genital system disease. This article reviews the expression,effect and possible mechanisms of miR-4 2 4 in non-tumorous diseases.

关 键 词：miR-424 血管生成 神经系统 脑卒中 生殖系统 

分 类 号：R-332[医药卫生]