糖尿病治疗药物及其合成进展  

Advances in anti-diabetes drugs and their synthesis

作　　者：朱芳莹[1,2] 董正伟[1,2] 朱文渊[1,2] 柳志强[1,2] 

机构地区：[1]浙江工业大学生物工程研究所,浙江杭州310014 [2]生物转化与生物净化教育部工程研究中心,浙江杭州310014

出　　处：《发酵科技通讯》2016年第3期175-181,共7页Bulletin of Fermentation Science and Technology

摘　　要：糖尿病是一种严重威胁人类健康的慢性疾病,而且患病率呈逐年上升趋势,糖尿病的治疗已成为全球性的重大公共卫生问题。介绍了糖尿病治疗药物及其分类,重点介绍了格列美脲、二甲双胍、罗格列酮、吡格列酮、阿卡波糖、伏格列波糖、瑞格列奈、那格列奈、西他列汀和维格列汀等重要降糖药物的作用机理、合成路线及应用等,以期为更加安全、有效、合理地选择降糖药物提供一定的依据。As a chronic disease, diabetes threatens human health seriously. The prevalence of diabetes is increasing annually, and the treatment of diabetes has become a major global public health problem. This paper introduced the anti-diabetes drugs and its classification. The mechanism, synthesis and application of some hypoglycemic drugs, such as glimepiride, metformin, rosiglitazone, pioglitazone, acarbose, voglibose, repaglinide, nateglinide, sitagliptin and vildagliptin, were especially introduced in this paper, aiming to provide some references for choosing more safe, effective and reasonable hypoglycemic drugs.

关 键 词：糖尿病 降糖药 合成 化学法 生物法 

分 类 号：R977[医药卫生—药品]