甲状腺乳头状癌组织趋化因子受体CXCR7和CCR5表达  

EXPRESSIONS OF CHEMOKINE RECEPTORS CXCR7 AND CCR5 IN PAPILLARY THYROID CARCINOMA

作　　者：李坤[1] 孙文海[1] 刘华敏[1] 董安兵 孙大为[1] 华辉[1] 

机构地区：[1]青岛大学附属医院甲状腺外科,山东青岛266003

出　　处：《齐鲁医学杂志》2016年第4期404-406,410,共4页Medical Journal of Qilu

摘　　要：目的研究趋化因子受体7（CXCR7）和趋化因子受体5（CCR5）在甲状腺乳头状癌（PTC）组织表达及其与PTC不同病理特征的关系。方法应用免疫组化的方法,检测70例PTC、25例甲状腺滤泡腺瘤及11例癌旁（距肿瘤2cm以上）组织中CXCR7及CCR5的表达情况。结果 PTC组织CXCR7和CCR5表达阳性率高于甲状腺滤泡腺瘤及癌旁组织,差异有显著性（χ~2=23.94、26.48,P〈0.05）;甲状腺滤泡腺瘤和癌旁组织中CXCR7和CCR5表达阳性率比较差异无显著性（P〉0.05）。Spearman相关分析显示,PTC组织中CXCR7和CCR5表达呈正相关（r=0.73,P〈0.05）。PTC组织中CXCR7和CCR5阳性表达与年龄、性别、TNM分期均无关（P〉0.05）,仅与淋巴结转移情况有关（χ~2=22.493、21.476,P〈0.05）。结论 CXCR7及CCR5可能对PTC的发展及转移起一定的促进作用。Objective To investigate the expressions of chemokine receptors CXCR7 and CCR5 and their association with different pathological characteristics in papillary thyroid carcinoma （PTC）. Methods The expressions of CCR5 and CXCR7 in 70 cases of PTC, 25 of thyroid adenoma and 11 of paracancerous tissues （distance from tumor more than 2 cm） were detected using immunohistochemical method. Results The positive rate of expressions of CXCR7 and CCR5 in PTC was higher than that in thyroid follicular adenoma and paracancerous tissues, the difference was significant （X^2=23.94,26.48;P〈0.05）. The difference in expressions of CXCR7 and CCR5 between thyroid follicular adenoma and paracancerous tissues was not significant （P〈0.05）. Spearman correlation analysis showed that the expression of CXCR7 was positively correlated with CCR5 in PTC （r=0.73, P〈0.05）. The positive expressions of CXCR7 and CCR5 in PTC tissue were not correlated with age, sex, and TNM stage （P〉0.05）, which were associated only with lymph node metastasis （X^2 =22.493,21.476,P〈0.05）. Conclusion CXCR7 and CCR5 possibly play a certain role in promoting the development and metastasis of papillary thyroid carcinoma.

关 键 词：甲状腺乳头状癌 趋化因子受体7 趋化因子受体5 

分 类 号：R736.1[医药卫生—肿瘤]