内镜下胃底组织胶注射联合套扎术治疗肝硬化食管胃底静脉曲张的效果及安全性  

Efficacy and safety of gastric fundus tissue adhesive injection under en-doscopy combined with variceal ligation in the treatment of esophageal and gastric varices with cirrhosis

作　　者：李洁[1] 范明娟[1] 辜金莲[1] 张龙[1] 

机构地区：[1]广州市第一人民医院老年病科,广东广州510180

出　　处：《中国当代医药》2016年第27期37-39,共3页China Modern Medicine

摘　　要：目的探讨内镜下胃底组织胶注射联合套扎术治疗肝硬化食管胃底静脉曲张的效果及安全性。方法选取我院2010年1月~2013年1月收治的90例肝硬化食管胃底静脉曲张患者作为研究对象,随机分为实验组和对照组,各45例。对照组采用套扎术治疗,实验组采用内镜下胃底组织胶注射联合套扎术治疗。比较两组的再出血率、静脉曲张消失率和不良反应发生率。结果实验组的再出血率为20.0%,低于对照组的40.0%,差异有统计学意义（P〈0.05）。实验组的静脉曲张消失率为40.0%,显著高于对照组的8.9%,差异有统计学意义（P〈0.01）。实验组的不良反应发生率为31.1%,显著低于对照组的46.7%,差异有统计学意义（P〈0.01）。结论内镜下胃底组织胶注射联合套扎术治疗肝硬化食管胃底静脉曲张效果显著,复发率低,安全性高。Objective To explore the effect and safety of gastric fundus tissue adhesive injection under endoscopy combined with variceal ligation in the treatment of esophageal and gastric varices（EGV） with cirrhosis.Methods 90 cases of EGV with cirrhosis in our hospital from January 2010 to January 2013 were selected and randomly divided into the experiment group and the control group,45 cases in each group.The control group was given variceal ligation,and the experiment group was given gastric fundus tissue adhesive injection under endoscopy combined with variceal ligation.The re-bleeding rate,the disappearing rate of varices and the incidence rate of adverse reaction in the two groups was compared.Results The re-bleeding rate of the experimental group was 20.0%,which was lower than 40.0% of the control group,with significant difference（P〈0.05）.The disappearing rate of varices in the experimental group was 40.0%,which was lower than 8.9% in the control group,with significant difference（P〈0.01）.The incidence rate of adverse reaction in the experimental group was 31.1%,which was lower than 46.7% in the control group,with significant difference（P〈0.01）.Conclusion Gastric fundus tissue adhesive injection under endoscopy combined with variceal ligation in the treatment of EGV with cirrhosis has significant curative effects,with low relapse rate and high safety.

关 键 词：内镜 组织胶注射 套扎术 胃底静脉曲张 

分 类 号：R571.3[医药卫生—消化系统]