SV25T4非球面多焦散光矫正人工晶体的兔眼实验研究  

Experimental Study on SV25T4 AcrySof IQ ReSTOR Multifocal Toric Intraocular Lens in Rabbits

作　　者：方丽 赵金川 李雪来 周森婷 周绮梦 冯勤 陈献花 FANG Li ZHAO Jing-chuan LI Xue-lai ZHOU Sen-ting ZHOU Qi-meng FENG Qin CHEN Xian-hua(Zhejiang Institute of Medical Device Supervision and Testing, Hangzhou 310018, China)

机构地区：[1]浙江省医疗器械检验院,浙江省医疗器械安全性评价研究重点实验室,杭州310018

出　　处：《实验动物与比较医学》2016年第4期285-289,共5页Laboratory Animal and Comparative Medicine

基　　金：浙江省科技计划项目（2013F10055）

摘　　要：目的 通过观察兔眼植入SV25T4非球面多焦散光矫正人工晶体（IOL）后的炎症反应,对其植入眼内的生物相容性和有效性进行评价.方法 取眼球无异常的兔24只,正常晶体超声乳化后,左眼作为试验眼,植入SV25T4非球面多焦散光矫正IOL;右眼为对照眼,植入SN6AD非球面多焦IOL.术后1d、7d和1月、3月、6月用裂隙灯观察及测量眼压.术后6月取出IOL进行光学性能评价,摘除的眼球进行病理组织学检查.结果 试验眼与对照眼均在术后1d出现轻度角膜水肿、前房闪辉现象,术后7d即明显好转,各观察期组间各项指标比较无显著性差异（P＞0.05）;植入后取出的IOL通过检测显示,其光学性能良好;眼球病理组织学检查显示,睫状体轻度充血,偶见淋巴细胞浸润.结论 SV25T4非球面多焦散光矫正IOL具有良好的生物相容性,能满足作为眼植入材料应用于白内障手术的安全性和有效性要求.Objective To evaluate the intraocular biocompatibility by observing inflammatory reac- tion after implantation of SV25T4 AcrySof IQ ReSTOR multifocal toric intraocular lens （IOLs） in rabbits. Methods Left eyes were performed phacoemulsification with SV25T4 AcrySof IQ ReSTOR multifocal toric intraocular lens implantation and right eyes were performed phacoemulsification with SNrAD AcrySof IQ ReSTOR multifoeal intraocular lens implantation in 24 rabbits. All of the eyes were examined with slitlamp microscope and measured the intraocular pressure at the 1 st, 7th days and 1 st, 3rd,6th months postoperatively. The explanted IOLs were assessed for optical properties. The enucle- ated eyes were performed histopathological evaluations. Results There were mild corneal edema and anterior chamber flare in both eyes at 1 stday postoperatively, obviously improved at 1 st week postoperatively, there is no significant difference between two groups during the observation period （P〉0.05）. Optical testing items of the explanted IOLs were in accord with the requirement of YY0290.2-2009. Histopathological observation showed mild hyperemia of ciliary body and few lympho- cytes infiltration. Conclusion The SV25T4 AcrySof IQ ReSTOR multifocal toric intraocular lens has good biocompatibility, meeting for the requirement of safety and validity as material of ocular implants in cataract surgery.

关 键 词：人工晶体(IOL) 散光 多焦 生物相容性 INTRAOCULAR lens (IOLs) 

分 类 号：R779.66[医药卫生—眼科] R-332[医药卫生—临床医学]