基于开端同轴射频组织介电特性测量技术的乳腺癌及癌周组织鉴别检测实验研究  

Experimental Research on Detection of Breast Carcinoma and Adjacent Tissues Based on Open-ended Coaxial Probe Tumor Sensor with Radio Frequencies

作　　者：陈妙良 陈建国[2] 魏珊珊[2] 符芳翔 徐彩玲[2] 冯晓创 段晶晶[2] 厉周[1] 辛学刚[3] 韩帅[1] 王卫卫[1] 段松[3] 邓官华 CHEN Miaoliang CHEN Jianguo WEI Shanshan FU Fangxiang XU Cailing FENG Xiaochuang DUAN Jingjing LI Zhou XIN Xuegang HAN Shuai WANG Weiwei DUAN Song DENG Guanhua(Zhujiang Hospital of Southern Medical University, Department of General Surgery, Guangzhou 510515, China Southern Medical University, Second Clinical Medical College, Guangzhou 510515, China Southern Medical University, School of Biomedical Engineering, Guangzhou 510515, China)

机构地区：[1]南方医科大学珠江医院普通外科,广州510515 [2]南方医科大学第二临床医学院,广州510515 [3]南方医科大学生物医学工程学院,广州510515

出　　处：《生物医学工程学杂志》2016年第5期958-962,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(61172034;61528102);广东省省级大学生创新创业训练资助项目(201512121127)

摘　　要：本文目的在于探讨开端同轴射频组织介电特性测量技术实时鉴别检测乳腺癌及癌周组织的可行性。16例新鲜乳腺导管癌标本来自珠江医院普外科，标本切除后立即应用开端同轴线肿瘤射频设备在射频频率42.85-500 MHz下，进行乳腺癌灶及远隔癌灶3 cm、5 cm组织的介电常数与电导率探测，并对各个探测点进行组织病理学检查。对乳腺癌组织与癌周3 cm组织、乳腺癌组织与癌周5 cm组织之间进行比较，电导率与介电常数差异均有统计学意义（P＜0.01）；癌周3 cm组织与癌周5 cm组织的电导率及介电常数差异无统计学意义（P＞0.05）。病理检查证实：癌周3 cm组织及癌周5 cm组织均未见癌细胞浸润。开端同轴线肿瘤射频技术能有效探测乳腺癌组织与癌周组织的介电特性差异，具有应用于乳腺癌辅助诊断的广阔前景。This study aimed to verify whether the open-ended coaxial line tumor sensor with radio frequency was effective or not in detecting the differences in permittivity and conductivity between the breast malignant tissues and adjacent tissues. Sixteen breast infiltrating ductal carcinoma samples were freshly obtained from the department of general surgery in Zhujiang Hospital. The permittivity and conductivity of cancerous nidus points of breast samples, 3 cm adjacent tissue points and 5 cm adjacent tissue points were detected respectively by the open-ended coaxial line tumor sensor with radio frequency noninvasively in conjunction with vector network analyzer at the frequency ranging from 42.85-500 MHz. All the detected points were marked. After finishing the detection, we conducted postoperative pathological examinations on all the marked points. According to the statistics, there were statistically significant differences between the breast cancerous tissues and the 3 cm adjacent tissues for the dielectric properties （P 〈 0.01）. There were statistically significant differences between the breast cancerous tissues and the 5 cm adjacent tissues for the dielectric properties （P 〈 0.01）. There was no statistically significant difference in the dielectric properties between the 3 cm adjacent tissues and 5 cm adjacent tissues （P 〉 0.05）. Both the 3 cm adjacent tissues and 5 cm adjacent tissues were found no breast cancer cell infiltration. The results indicated that the open-ended coaxial line tumor sensor at radio frequency could be effective in detecting the differences in permittivity and conductivity between breast cancerous tissues and adjacent tissues and, therefore, it may have a potential prospect in making a final diagnosis to confirm whether the detected breast tissue is malignant or not.

关 键 词：开端同轴线 乳腺导管癌 电导率 介电常数 

分 类 号：R737.9[医药卫生—肿瘤]