帕金森病患者手指开合动作规律性的量化评估  

Quantitative Evaluation of Regularity of Finger Tapping Movement for Patients with Parkinson's disease

作　　者：刘遥[1,2] 王训[3] 许胜强 程楠[1,3] 唐正[1] 孙怡宁[1] 杨先军[1] LIU Yao WANG Xun XU Shengqiang CHENG Nan TANG Zheng SUN Yining YANG Xianjun(Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China Department of Automation, University of Science and Technology of China, Hefei 230026, China Hospital Affiliated to Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei 230061, China)

机构地区：[1]中国科学院合肥智能机械研究所,合肥230031 [2]中国科学技术大学自动化系,合肥230026 [3]安徽中医药大学神经病学研究所附属医院,合肥230061

出　　处：《生物医学工程学杂志》2016年第5期979-984,共6页Journal of Biomedical Engineering

基　　金：国家科技支撑计划资助项目(2013BAH14F01);安徽省科技攻关计划资助项目(1301042215;1501021042)

摘　　要：临床上,手指开合动作测试是神经内科对帕金森病(PD)患者运动能力的一个常用检测项目,它主要从动作幅度、速度和规律性三个方面评价患者的手部精细运动能力。本文旨在关注PD患者手指开合动作规律性的量化评估,用惯性传感器单元采集测试对象在手指开合过程中食指和拇指的运动信号,计算近似熵(ApEn)和样本熵(SampEn)两个非线性动态指标,然后对计算结果进行统计分析。试验结果表明,两个指标不仅在病例组和对照组之间有较大差异,而且与临床医生给出的统一帕金森病评分量表(UPDRS)对应项评分有较高的相关性,说明两个指标均能够在一定程度上反映帕金森病患者手指重复性动作的受损程度,可以作为临床上对帕金森病患者运动能力评估的一种可靠方法。Finger tapping test is a common testing item for patients with Parkinson＇s disease （PD） in clinical neurology. It mainly evaluates the fine motor function of patient＇s hand in three aspects： amplitude, speed and regularity of the movement. This paper focused on the quantitative assessment of regularity of finger tapping movement for PD patients. The movement signals of thumb and index finger were recorded by using inertial sensor unit in the process of tapping test. Two nonlinear dynamic indexes, approximate entropy （ApEn） and sample entropy （SampEn）, were calculated, and then the values were statistically analyzed. The experimental results indicated that both indexes had significant differences between patient group and control group. Moreover, the indexes had relatively high correlation with the scores of corresponding unified Parkinson＇s disease rating scale （UPDRS） item rated by clinical clinician, which illustrated that these two indexes could reflect the injury level of the repetitive finger movement. So, as a relia- ble method, it can be provided to the clinical evaluation of hand movement function for PD patients.

关 键 词：手指开合动作测试 帕金森病 规律性 量化评估 近似熵 样本熵 

分 类 号：R742.5[医药卫生—神经病学与精神病学]