Sigma-1 receptor and neuroprotection:current outlook and potential therapeutic effects  

作　　者：Giovanni Li Volti Paolo Murabito 

机构地区：[1]Department of Biomedical and Biotechnological Sciences,University of Catania [2]Azienda Ospedaliera Universitaria Policlinico "G. Rodolico",University of Catania

出　　处：《Neural Regeneration Research》2016年第9期1392-1393,共2页中国神经再生研究（英文版）

摘　　要：Oxidative stress plays a major role in neurodegenerative disease since central nervous system is particularly vul- nerable to reactive oxygen species （ROS） due to several reasons： high consumption ROS and nitrosative species, of O2; high production of which originate from spe- cific neurochemical reactions （e.g., dopamine oxidation）; high deposition of metal ions in the brain with aging leading to Fenton＇s reactions; high abundance of lipids which are particularly sensitive to oxidation.Oxidative stress plays a major role in neurodegenerative disease since central nervous system is particularly vul- nerable to reactive oxygen species （ROS） due to several reasons： high consumption ROS and nitrosative species, of O2; high production of which originate from spe- cific neurochemical reactions （e.g., dopamine oxidation）; high deposition of metal ions in the brain with aging leading to Fenton＇s reactions; high abundance of lipids which are particularly sensitive to oxidation.

关 键 词：MCAO Sigma-1 receptor and neuroprotection 

分 类 号：R741[医药卫生—神经病学与精神病学]