Anesthesia-induced neurotoxicity in an animal model of the developing brain:mechanism and therapies  

作　　者：Maiko Satomoto Koshi Makita 

机构地区：[1]Department of Anesthesiology,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University

出　　处：《Neural Regeneration Research》2016年第9期1407-1408,共2页中国神经再生研究（英文版）

基　　金：supported by the Japan Society for the Promotion of Science,Tokyo,Japan;Grant No.23890054 and 25861361

摘　　要：Children are being exposed to an increasingly greater variety of anesthetics with advances in pediatric and obstetric surgery. Recent animal and retrospective human data suggest that the general anes- thetics commonly used in pediatric medicine could he damaging to the developing brain when used at clinical concentrations. In viw~ primate and rodent models have shown that neonatal exposure to clinical concentrations of anesthetics causes neural apoptosis and long-term cognitive impairment. Many general anesthetics.Children are being exposed to an increasingly greater variety of anesthetics with advances in pediatric and obstetric surgery. Recent animal and retrospective human data suggest that the general anes- thetics commonly used in pediatric medicine could he damaging to the developing brain when used at clinical concentrations. In viw~ primate and rodent models have shown that neonatal exposure to clinical concentrations of anesthetics causes neural apoptosis and long-term cognitive impairment. Many general anesthetics.

关 键 词：Anesthesia-induced neurotoxicity in an animal model of the developing brain NADPH 

分 类 号：R-332[医药卫生] R726.1