Current perspectives on the antidepressant-like effects of guanosine  

作　　者：Luis E.B.Bettio Joana Gil-Mohapel Ana Lucia S.Rodrigues 

机构地区：[1]Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis-SC, Brazil [2]Division of Medical Sciences and UBC Island Medical Program,University of Victoria, Victoria, BC, V8W 2Y2, Canada

出　　处：《Neural Regeneration Research》2016年第9期1411-1413,共3页中国神经再生研究（英文版）

基　　金：funding from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq;#403120/2012-8,#308723/2013-9,#449436/2014-4);Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES),Brazil

摘　　要：Purines have a recognized importance as intercellular mes- sengers. These molecules play an important role in the de- velopment and maintenance of the central nervous system （CNS）, as well as in its response to pathological conditions. Both adenine and guanine-based purines can be released from astrocytes, where they play a relevant role as extracel- lular signaling molecules. Particularly, the nucleoside gua- nosine has been proposed as an extracellular molecule that regulates the response of CNS to damage. Following injury, this nucleoside attains high concentrations in the extracel- lular space, where it activates multiple signaling pathways.Purines have a recognized importance as intercellular mes- sengers. These molecules play an important role in the de- velopment and maintenance of the central nervous system （CNS）, as well as in its response to pathological conditions. Both adenine and guanine-based purines can be released from astrocytes, where they play a relevant role as extracel- lular signaling molecules. Particularly, the nucleoside gua- nosine has been proposed as an extracellular molecule that regulates the response of CNS to damage. Following injury, this nucleoside attains high concentrations in the extracel- lular space, where it activates multiple signaling pathways.

关 键 词：Current perspectives on the antidepressant-like effects of guanosine 

分 类 号：R741[医药卫生—神经病学与精神病学]