子宫动脉栓塞联合药物治疗子宫肌瘤的疗效研究  

Research of therapeutic effects of uterine artery embolization combined with drug therapy in treatment of uterus myoma

作　　者：伊丽娜[1] 张丽敏[1] 刘炯鸥[2] 

机构地区：[1]内蒙古自治区赤峰市医院妇科,024000 [2]内蒙古医科大学附属医院超声科,呼和浩特010050

出　　处：《中华妇幼临床医学杂志（电子版）》2016年第5期547-552,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(81060120)~~

摘　　要：目的探讨子宫动脉栓塞（uAE）联合药物（宫瘤消胶囊）治疗子宫肌瘤（UM）的临床疗效。方法选择2012年3月至2013年4月于内蒙古自治区赤峰市医院诊断为UM的40例患者为研究对象。按照uM患者接受的治疗方式，将其分为研究组（n=20，UAE联合宫瘤消胶囊治疗）与对照组（n=20，单纯UAE治疗）。观察两组患者治疗后不良反应发生情况，以及治疗前与治疗后3、6、12个月时的月经情况（月经周期、月经期）及UM体积，并对上述指标进行统计学分析。两组患者年龄、体重、产次、孕次及治疗前月经周期、月经期、UM体积等一般临床资料比较，差异均无统计学意义（P〉0．05）。结果①不良反应率比较：治疗后，研究组患者下腹部疼痛率为5．0％（1／20），显著低于对照组的35．0％（7／20），并且差异有统计学意义（χ2=5．625，P=0．018）；两组患者发热、恶心呕吐、肢体乏力及阴道不规则出血等不良反应率比较，差异均无统计学意义（P〉0．05）。②月经周期比较：两组患者月经周期的组间×时间因素比较，无交互效应，差异无统计学意义（F组间×时间=0．593，P=0．555），而且治疗前、后，月经周期的时间与组间因素分别比较，差异亦均无统计学意义（F时间=0．103，P=0．902；F时间=0．057，P=0．813）。月经期比较：两组患者月经期的组间×时间因素比较，存在交互效应，差异有统计学意义（F时间=3．982，P=0．022），而且治疗前、后，月经期的时间与组间因素分别比较，差异亦均有统计学意义（F时间=138．216，P=0．000；F时间=4．179，P=0．048）；两组治疗后3、6及12个月时，组内分别与治疗前比较，均显著缩短，并且差异均有统计学意义（研究组：t=4．155，P=0．001；t=7．559，P=0．000；t=8．340，P=0．000；对照组：t=3．075，P=0．006；t=6．155，P=0．000；t=6．373，P=0�Objective To explore the therapeutic effects of uterine artery embolization （UAE） combined with drug therapy in treatment of uterus myoma （UM）. Methods From March 2012 to April 2013, a total of 40 cases of patients who were diagnosed as UM in Inner Mongolia Autonomous Region Chifeng Municipal Hospital and received treatments were selected into this study as research subjects. According to the treatment methods UM patients received, they were divided into study group （n=20, received UAE combined with uterine tumor eliminator capsule treatment） and control group （n=20, received UAE treatment alone）. Adverse reactions after treatment and menstruation （menstrual cycle and period） and UM volume before treatment and 3, 6, 12 months after treatment of two groups were observed and were analyzed by statistical methods. There were no statistical differences between two groups among age, body weight, parity, gravidity, menstrual cycle and menstrual period and UM volume before treatment and so on （P〉0.05）. Results （DAfter treatment, the incidence of hypogastrium pain in study group was 5.0% （1/20） which was significantly lower than 35.0% （7/20） in control group, and the difference was statistically significant （χ2 = 5. 625, P= 0. 018）. While there were no statistical differences between two groups among the incidences of fever, nausea and vomiting, limb weakness and irregular vaginal bleeding （P〉 0. 05）. （3）There was no interaction effect between group and time factor in menstrual cycles, and the difference was not statistically significant （Fgroup×time = 0. 593, P= 0. 555）. There were no statistical differences among the menstrual cycles before and after treatment at different times （Fgroup×time = 0. 103, P = 0. 902） and between two groups （Fgroup= 0.057, P = 0. 813）. There was interaction effect between group and time factor in menstrual period, and the difference was statistically significant （Fgroup×time = 3. 982, P = 0. 022）. There were statistical

关 键 词：子宫动脉栓塞术 药物疗法 肌瘤 子宫 月经失调 不良反应 宫瘤消胶囊 

分 类 号：R737.33[医药卫生—肿瘤]