磁共振扩散峰度成像鉴别诊断肾细胞癌亚型的可行性分析  

Feasibility of diffusion kurtosis imaging in differential diagnosis of subtypes of renal cell carcinoma

作　　者：刘伟锋[1] 陈亮[1] 江新青[1] 

机构地区：[1]广州市第一人民医院放射科,广东广州510108

出　　处：《哈尔滨医科大学学报》2016年第4期333-336,共4页Journal of Harbin Medical University

摘　　要：目的探讨磁共振扩散峰度成像(diffusion kurtosis imaging,DKI)技术鉴别肾细胞癌主要亚型的可行性。方法搜集44例经手术病理证实的肾癌患者资料,其中肾透明细胞癌(clear cell renal cell carcinoma,CCRCC)24例,乳头状肾细胞癌(papillary renal cell carcinoma,PRCC)20例,所有患者均行DKI扫描(b value=0,500,800 s/mm2,采样时间是110 s),对比分析两种肾癌亚型患者DKI差异,主要包括弥散(mean diffusivity,MD),表现各向异性指标(fractional anisotropy,FA),峰度各向异性(kurtosis anisotropy,KA),并与病理结果进行比较。结果 24例CCRCC和20例PRCC两两比较,MD:7.13±1.19 vs0.68±0.11,P=0.01;FA:0.72±0.11 vs 0.76±0.14,P=3.24;KA:0.49±0.13 vs 2.89±1.11,P=0.02。结论 DKI技术对CCRCC和PRCC的鉴别诊断具有一定价值,可以为临床判断预后提供依据。Objective To characterize diffusion kurtosis imaging （DKI） of clear cell renal cell carcinoma （CCRCC） and papillary renal cell carcinoma （PRCC）. Methods The data of 24 patients with CCRCC and 20 patients with PRCC proved by operation and pathology were retro- spectively studied. Tumor DKI features （b value = 0, 500, 800 s/mm^2）, including mean diffusivity （MD）, fractional anisotropy （ FA）, kurtosis anisotropy （KA） were assessed. And the DKI features were compared with the pathologic results. Results The comparison results of the two groups （24 patients with CCRCC and 20 patients with PRCC） were as follows. MD： 7. 13 ±1. 19 vs0.68±0. 11, P=0.01; FA： 0.72±0.11 vs 0.76 ±0. 14, P=3.24; KA： 0. 49 ±0. 13 vs 2. 89± 1.11, P =0. 02. Conclusion DKI is valuable of differential diagnosis of CCRCC and PRCC, and could provide the basis for clinical prognosis judgement.

关 键 词：肾癌 亚型 扩散峰度成像 凋亡 

分 类 号：R737.11[医药卫生—肿瘤] R445.2[医药卫生—临床医学]