液体活检和肿瘤精准医疗  

Liquid biopsy and precision medicine for oncology

作　　者：许扬梅[1] 郑秋红[1] XU Yangmei ZHENG Qiuhong(Key Laboratory of Tumor Biotherapy of Fujian Province, National Clinical Key Specialty of Tumor, Tumor Hospital of Fujian Province, Tumor Hospital Affiliated to Fujian Medical University, Fuzhou 350014, Fujian, China)

机构地区：[1]福建医科大学附属肿瘤医院,福建省肿瘤医院国家临床重点肿瘤专科,福建省肿瘤生物治疗重点实验室,福建福州350014

出　　处：《中国肿瘤生物治疗杂志》2016年第5期589-594,共6页Chinese Journal of Cancer Biotherapy

基　　金：国家临床重点专科建设项目资助;福建省临床重点专科建设项目资助;福建省医学创新项目(No.2015-CXB-4);~~

摘　　要：精准医疗新技术——液体活检,既有极高的科研价值,又具备助力推进精准医疗临床实践的巨大潜能。它可用于癌症早期筛查、诊断、监控、治疗方案指导和疗效评估等众多领域,液体活检的优势使其成为最具发展潜力的肿瘤诊疗手段。本文围绕液体活检在临床肿瘤精准医疗的应用前景,从概念、特点、研究方法和个体化肿瘤治疗、临床应用及研究现状等方面进行阐述,展示了液体活检巨大的临床应用价值和市场前景。Liquid biopsy, as a novel technique of precision therapy, has a very high scientific research value, but also has great potential power to promote clinical practice of precision therapy, which can be applied in more fields of early screening, diagnosis, monitoring, guiding theraputic program and efficacy evaluation of tumor, and so on. Advantages of the liquid biopsy make it become the most development potential approach for diagnosis and therapy of tumor. This article elucidated application prospects of the liquid biopsy in clinical precision therapy of tumor from the views of conceptions, characters, research methods, individualized tumor therapy, clinical applications, research status and so on, and showed huge clinical application value and market prospect of the liquid biopsy.

关 键 词：液体活检 精准医疗 循环肿瘤细胞 循环肿瘤DNA 循环肿瘤干细胞 

分 类 号：R730.4[医药卫生—肿瘤] R730.58[医药卫生—临床医学]