维生素在肿瘤干细胞信号传导通路中的作用机制探讨  

The Signal Transduction Mechanisms of Vitamins on Cancer Stem Cells

作　　者：罗昊翔[1] Luo Haoxiang(Southwest of Guizhou Vocational and Technical College for Nationalities, Xingyi, 56240)

机构地区：[1]黔西南民族职业技术学院医药系,兴义562400

出　　处：《基因组学与应用生物学》2016年第9期2269-2274,共6页Genomics and Applied Biology

基　　金：贵州省科技厅科学技术基金项目(黔科合J字[2013]2268号)资助

摘　　要：肿瘤干细胞的形成是一个多环节、多步骤的过程,其中维生素缺乏,可导致细胞信号传导改变,使细胞发育不良。维生素长期缺乏导致的细胞适应性变化可能与肿瘤干细胞的形成和维持有关。本综述主要探讨维生素信号传导导致肿瘤干细胞形成的机制,为肿瘤的预防和治疗提供理论依据。The formation of cancer stem cell was a process of multi-level and multi-step, of which, the deficiency of vitamin can cause signal transduction alternation of cells, so that the cells will be dysplasia. Over a long period of time, the cells will adapt to the microenvironment of vitamin deficiency, which may be related to the formation and maintenance of the cancer stem cell. This review mainly introduced the signal transduction mechanisms of vitamins on cancer stem cells, to provide basis for cancer prevention and treatment.

关 键 词：维生素 肿瘤干细胞 信号传导 激酶 代谢 

分 类 号：R730.2[医药卫生—肿瘤]