长链非编码RNA与恶性肿瘤发生发展关系的研究进展  

The Relationship between the Long Noncoding RNA and the Occurrence,Development of Malignant Tumor

作　　者：邓镇涛[1] 许朋[2] 王燕[1] Deng Zhentao Xu Peng Wang Yan(Zhuhai Campus of Zunyi Medical College, Zhuhai, 519041 Zunyi Medical College, Zunyi, 563000)

机构地区：[1]遵义医学院珠海校区,珠海519041 [2]遵义医学院,遵义563000

出　　处：《基因组学与应用生物学》2016年第9期2286-2288,共3页Genomics and Applied Biology

基　　金：贵州省社会发展科技攻关项目(黔科合0Z字[2009]2)资助

摘　　要：人类基因组数目庞大,其形成的基因调控网络控制着组织、器官细胞的增殖、分化和凋亡。但是,整个基因组中仅约2%的基因是编码RNA,可以翻译成蛋白质,98%左右的基因为非编码RNA。之前人们普遍认为非编码RNA不能翻译有效的蛋白质产生相应的功能,被视为基因组中的"废物"。目前,大量研究表明非编码RNA并不是基因组序列中没用的产物,而是未知的"黑暗物质",已有大量的研究发现非编码RNA在多种生物过程中起着重要的作用,并且在一些重大疾病如肿瘤、心血管的发生发展中发挥着不可小觑的作用。本文就长链非编码RNA在恶性肿瘤的发生发展中的作用机制做一综述。The human genome is a very large number and it forms gene regulation networks which regulates the human genome organization, organ cell proliferation, differentiation and apoptosis. However, only about 2% of the entire genome genes can translate to encoding RNA, and then into coding protein. About 98% of the genes are non-coding RNA. It was widely believed that noncoding RNA was considered to be the ＂waste＂ of the genome, because it could not translate effective proteins and could not generate corresponding shapes. At present, a large number of studies have shown that noncoding RNA genome sequence is not the ＂waste＂, but some little-known ＂dark matter＂, which may play an important role in the development of some serious diseases such as cancer, and cardiovascular.

关 键 词：长链非编码RNA 恶性肿瘤 肿瘤发生 

分 类 号：R730.2[医药卫生—肿瘤]