循环肿瘤细胞在胰腺肿瘤中的检测和临床应用  

Detection and clinical application of circulating tumor cells in pancreatic neoplasm

作　　者：吕洋[1] 浦宁[1] 许雪峰[1] 

机构地区：[1]复旦大学附属中山医院普通外科复旦大学普通外科研究所,上海200032

出　　处：《中华消化外科杂志》2016年第10期1033-1036,共4页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金（81572294）

摘　　要：胰腺肿瘤是消化道常见肿瘤，其诊断、治疗及预后判断较为困难。循环肿瘤细胞（CTCs）的检测是近年来的研究热点，且在许多肿瘤中已被证实对诊断、治疗及预后具有提示作用。本文针对CTCs现有的富集、检测方法及其在胰腺肿瘤诊断与治疗中的研究进展进行概括、总结并提出CTCs的应用前景。Pancreatic neoplasm is one of the most commonly appeared digestive tumors and has been well recognized as the poor diseases which have the difficulties in diagnosis, treatment and prognosis estimation. Recently, the detection of circulating tumor cells （CTCs） has been a pretty highlight of the research on detecting tumor cells in peripheral blood, and furthermore, the clinical value in the diagnosis, treatment and prognosis prediction has already been verified through a large amount of samples analyses in various kinds of tumor diseases. This paper aims to review and conclude the techniques of CTCs enrichment, detection and clinical implications in pancreatic neoplasms. In addition, the existing papers have been summarized and prospect of application of CTCs is also presented.

关 键 词：胰腺肿瘤 循环肿瘤细胞 诊断 治疗 预后 

分 类 号：R735.9[医药卫生—肿瘤]