并发心房颤动对急性脑血管病患者相关指标的影响及病理意义  

The effects and pathological significance of peripheral inflammatory factors,vWF and ODI in atrial fibrillation complicated with acute cerebrovascular disease patients

作　　者：陈庆友[1] 张艳蕉[1] 王中华[2] 

机构地区：[1]齐齐哈尔医学院附属第三医院神经内科,黑龙江齐齐哈尔161000 [2]哈尔滨医科大学第一临床医学院心内科,哈尔滨150001

出　　处：《重庆医学》2016年第29期4083-4085,共3页Chongqing medicine

摘　　要：目的考察并发心房颤动(AF)对急性脑血管病患者外周血炎性因子,血管性假血友病因子(vWF)与氧减饱和度指数(ODI)的影响及病理意义。方法收集2013年4月至2015年3月在齐齐哈尔医学院附属第三医院收治的急性脑血管病患者132例,按是否并发AF分为2组:并发AF的急性脑血管病组60例,非AF的急性脑血管病组72例。选择同期健康体检者67例为对照组。结果与急性脑血管病组比,并发AF的急性脑血管病组脑出血、意识障碍、既往脑血管病史和大脑中动脉发病例数较多(P<0.05)。与对照组比较,急性脑血管病组神经功能缺损评分(NIHSS)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、vWF和ODI增高(P<0.05),与急性脑血管病组比,并发AF急性脑血管病组NIHSS、IL-6、TNF-α、CRP、vWF和ODI明显增高(P<0.05)。结论 AF加重了急性脑血管病患者的炎症反应、血管内皮功能紊乱和低氧并存的状况。Objective To investigate the effects and pathological significance of peripheral inflammatory factors,vov wille- brand factor （vWF） and oxygen desaturation index （ODD in atrial fibrillation complicated with acute cerebrovascular disease pa- tients. Methods From April 2013 to March 2015,132 cases of acute cerebrovascular disease patients in our hospital were divided into 2 groups：60 cases of acute cerebrovascular disease complicated with atrial fibrillation and 72 cases of acute cerebrovascular dis- ease, 67 cases healthy volunteers were chosen as the control. Results Compared with acute cerebrovascular disease group,the cases of brain bleeding, unconsciousness, history of cerebrovascular disease and cerebral artery had increasesd in the acute cerebrovascular disease complicated with atrial fibrillation group（P〈0.05）. Compared with control group, the patients＇ NIHSS, IL-6, TNF-α, CRP, vWF and ODI increased （P〈0.05）. Compared with acute cerebrovascular disease group, the NIHSS, IL-6, TNF-α, CRP, vWF and ODI had increased in the acute cerebrovascular disease complicated with atrial fibrillation group （P〈0.05）. Conclusion The condi- tion of atrial fibrillation could worsen the inflammation,endothelial dysfunction and hypoxia coexist situation in patients with acute cerebrovascular disease.

关 键 词：心房颤动 急性脑血管病 炎性因子 血管性假血友病因子 氧减饱和度指数 

分 类 号：R743.3[医药卫生—神经病学与精神病学]