基于证素辨证的慢性胃炎常见病位间的气味图谱特征研究  

Study of characteristics of odor response patterns among the common syndrome elements of the location of the disease of chronic gastritis based on differentiation of syndrome elements

作　　者：林雪娟[1,2] 梁丽丽[1,2] 刘丽桑[3] 吴青海[1,2] 郭森仁 李灿东[1,2] 

机构地区：[1]福建中医药大学中医证研究基地,福州350122 [2]福建省中医健康状态辨识重点实验室(福建中医药大学),福州350122 [3]福建工程学院,福州350118 [4]福建中医药大学附属晋江中医院,晋江362200

出　　处：《中华中医药杂志》2016年第10期3966-3969,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81373552);福建省自然科学基金项目(No.2014J01362);福建省中医药科研项目(No.wzpw201313);福建省教育厅A类项目(No.JA14212);福建省发改委产业技术开发项目~~

摘　　要：目的:运用电子鼻探讨慢性胃炎患者及其常见病位间口腔呼气的气味图谱特征。方法:选择618例慢性胃炎患者和120名健康者,运用基于阵列式气体传感器技术的医用电子鼻采集口腔呼气的气味图谱,采用证素辨证方法分析慢性胃炎的常见病位,借助支持向量分类机的方法识别慢性胃炎患者和健康者的气味图谱特征,同时选择气味图谱响应曲线的振幅和斜率作为图谱特征参数,比较慢性胃炎常见病位间的气味图谱特征。结果:1选择高斯核对慢性胃炎患者和健康者的气味图谱特征的识别准确率高达88.53%。2响应曲线的振幅特征比较:慢性胃炎患者病位肝组的气味图谱响应曲线B、C、D、E、F、I、J的振幅显著高于病位胃组(P<0.01),病位肝组的气味图谱响应曲线E、F、I、J的振幅高于病位脾组(P<0.05)。3响应曲线的斜率特征比较:慢性胃炎患者病位肝组的气味图谱响应曲线A、B、C、D、E、F、I的斜率显著高于病位胃组(P<0.01),病位肝组的气味图谱响应曲线A、E、F、I的斜率高于病位脾组(P<0.05)。结论:运用电子鼻可以较准确地识别慢性胃炎患者口腔呼气的气味特征,并能初步判断慢性胃炎常见病位间的气味差异。Objective： To explore the odor response patterns characteristics of chronic gastritis（CG） based on differentiation of syndrome elements by electronic nose. Methods： Six hundred and eighteen cases of patients with CG and 120 healthy volunteers were included into this study. The exhalation odor response patterns characteristics were recorded by medical electronic nose that was based on array gas sensor technology. The differentiation of syndrome elements was used to analyze common disease location of CG. The odor response pattern characteristics were recognized by the support vector classification, and then its amplitude and slope were selected as the parameters to compare the difference between CG patients and healthy volunteers. Results： 1The support vector classification effectively recognized the odor response pattern characteristics, with 88.53% of accuracy rate. 2The results of the amplitude showed that the odor response pattern curves B, C, D, E, F, I and J in the liver was significantly higher than that in the stomach（P〈0.01）, and the odor response pattern curves E, F, I and J in the liver was higher than that in the spleen（P〈0.05）. 3The results of the slope demonstrated that the odor response pattern curves A, B, C, D, E, F and I in the liver was significantly higher than that in the stomach（P〈0.01）, and the odor response pattern curves A, E, F and Iin the liver was higher than that in the spleen（P〈0.05）. Conclusion： Electronic nose could recognize the exhalation odor response patterns characteristics of CG patients, and therefore identify the differences among the varied disease locations.

关 键 词：嗅诊 电子鼻 慢性胃炎 病位 证素 气味图谱 特征 

分 类 号：R259[医药卫生—中西医结合]