硫化氢在动脉粥样硬化病变中的研究进展  

Research Progress of Hydrogen Sulfide in the Atherosclerotic Lesions

作　　者：李博[1] 周春阳[1] LI Bo and ZHOU Chun-Yang(School of Pharmacy, Institute of Materia Medica, North Sichuan Medical College, Nanchong, Sichuan 637007, Chin)

机构地区：[1]川北医学院药学院,川北医学院药物研究所,四川省南充市637007

出　　处：《中国动脉硬化杂志》2016年第9期963-968,共6页Chinese Journal of Arteriosclerosis

基　　金：四川省教育厅重点项目(13ZA0231);川北医学院药理学重点学科建设项目(2016)

摘　　要：动脉粥样硬化病变是导致心血管疾病发生率和死亡率居高不下的重要原因,对人们的生命健康安全产生严重危害。新近研究表明硫化氢作为气体信号分子在动脉粥样硬化病变中具有重要生理功能,其缺乏可能会导致动脉粥样硬化病变的早期发展。这篇综述从机体生物脂代谢异常、硫化氢与抗凝血关系、内皮细胞的增殖或迁移受到抑制等方面介绍了硫化氢在动脉粥样硬化发展中起到的保护作用,以及硫化氢可以改变动脉粥样硬化代谢的特征。本文也对今后进一步的工作提出了一定的设想与展望。Atherosclerosis（ As） is an important cause of high morbidity and mortality of cardiovascular disease.It has serious harm to people＇s health and safety of life. Recent studies show that hydrogen sulfide（ H2S） as a gaseous signal molecule has important physiological functions in As lesions,and its deficiency may lead to the early development of As lesions. This review describes the protective effects of H2 S in the development of As,from biological lipid metabolism disorders,relationship between H2 S and anti-coagulation,inhibition of endothelial cell proliferation or migration,and that H2 S can change the characteristics of As metabolism. This article also puts forward some ideas and prospects for the further works.

关 键 词：气体信号分子 硫化氢 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]