吸烟对帕金森病患者嗅觉障碍的影响  

The influence of smoking on olfactory disorder in patients with Parkinson's disease

作　　者：程永清[1] 沙志涛 田有勇[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)神经内科,210006

出　　处：《临床神经病学杂志》2016年第5期370-373,共4页Journal of Clinical Neurology

摘　　要：目的探讨吸烟对帕金森病(PD)患者嗅觉障碍的影响。方法根据吸烟情况将167例PD患者(PD组)及100例正常人(正常对照组)分为吸烟亚组及不吸烟亚组。采用T&T嗅觉测试液对入组者进行嗅素识别阈值测定。结果与正常对照组比较,PD组MMSE评分及蒙特利尔认知评估(Mo CA)评分显著降低(均P<0.05),两组年龄、吸烟史及男性比率未见明显差异(均P>0.05)。PD组嗅素识别阈显著高于正常对照组(t=6.785,P=0.000)。与PD吸烟亚组比较,不吸烟亚组嗅素识别阈显著升高(t=-3.000,P=0.003)。正常人吸烟亚组较不吸烟亚组嗅素识别阈值减低,但无统计学意义(t=0.784,P=0.435)。PD吸烟者嗅觉阈值与吸烟年限、吸烟总量无相关(r=-0.104,P=0.441;r=-0.156,P=0.246)。结论吸烟可能对PD患者嗅觉有保护作用,并且与吸烟年限、吸烟总量无关。Objective To explore the influence of smoking on olfactory disorder in Parkinson＇s disease（ PD）.Methods According to smoking or not,167 PD patients（ PD group） and 100 normal controls（ normal control group） were divided into smoking subgroups and non-smoking subgroups. The olfactory identification threshold was tested by TT olfactory assessment. Results Compared with normal control group,the scores of MMSE and montreal cognitive assessment in PD group were significantly decreased（ all P〈0. 05）,age,smoking history,the rate of male had no statistical significance（ all P〉0. 05）. The olfactory identification threshold in PD group was significantly higher than normal control group（ t = 6. 785,P = 0. 000）. Compared with PD smoking subgroup,the olfactory identification threshold in non-smoking subgroup was significantly higher（ t =- 3. 000,P = 0. 003）. The olfactory identification threshold in normal control smoking subgroup was significantly lower（ t = 0. 784,P = 0. 435）.The olfactory identification threshold of PD smokers had no correlation with smoking pack-years or duration（ r =-0. 104,P = 0. 441; r =- 0. 156,P = 0. 246）. Conclusion Smoking may protect olfactory disorder in PD patients,and it has no correlation with smoking pack-years or duration.

关 键 词：帕金森病 嗅觉障碍 吸烟 

分 类 号：R742.5[医药卫生—神经病学与精神病学]