淋巴血管侵犯对高级别T1期膀胱癌患者初次经尿道膀胱肿瘤电切术预后的影响  

Effect of lymphovascular invasion on prognosis in high-grade pT1 bladder cancer after first transurethral resection of bladder tumor

作　　者：李亚县[1] 张凯忠[1] 周立[1] 

机构地区：[1]南方医科大学附属茂名医院泌尿外一科,广东茂名525000

出　　处：《中国医师进修杂志》2016年第10期910-912,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的：分析淋巴血管侵犯（LVI）对高级别T1期膀胱癌患者初次施行经尿道膀胱肿瘤电切术（TURBT）预后的影响。方法选择初次行TURBT且术后病理结果显示LVI阳性的高级别T1期膀胱癌患者35例（观察组）和初次行TURBT且术后病理结果显示LVI阴性的高级别T1期膀胱癌患者70例（对照组），比较两组患者肿瘤复发率、肿瘤进展率、肿瘤无复发生存时间（RFS）、总生存时间（OS）。结果观察组随访15～71（42.1±18.1）个月，对照组随访20～72（50.9±12.2）个月。观察组肿瘤复发率和肿瘤进展率明显高于对照组[88.6％（31/35）比34.3％（24/70）和54.3％（19/35）比22.9％（16/70）]，差异有统计学意义（P＜0.01）。观察组RFS和OS明显短于对照组[（19.7±4.5）个月比（46.8±9.2）个月和（43.4±12.6）个月比（63.4±7.1）个月]，差异有统计学意义（P＜0.05）。结论 LVI与初次行TURBT的高级别T1期膀胱癌患者的肿瘤复发和进展有明显相关性，且LVI能预测患者疾病的进展以及不良的预后。Objective To explore the effect of lymphovascular invasion （LVI） on prognosis in the high-grade stage pT1 bladder cancer after first transurethral resection of bladder tumor （TURBT）. Methods Thirty-five high-grade stage pT1 bladder cancer patients who underwent first TURBT and showed LVI positive according to the postoperative pathological （observation group） and 70 high-grade stage pT1 bladder cancer patients who underwent first TURBT and showed LVI negative according to the postoperative pathological （control group） were enrolled into the study. The tumor recurrence rate, tumor progression rate, recurrence-free survival （RFS） and overall survival （OS） were compared between 2 groups. Results The follow-up time in observation group was 15 - 71 （42.1 ± 18.1） months, and in control group was 20-72 （50.9 ± 12.2） months. The tumor recurrence rate and tumor progression rate in observation group were significantly higher than those in control group：88.6%（31/35） vs. 34.3%（24/70） and 54.3%（19/35） vs. 22.9%（16/70）, and there were statistical differences （P〈0.01）. The RFS and OS in observation group were significantly shorter than those in control group： （19.7 ± 4.5） months vs. （46.8 ± 9.2） months and （43.4 ± 12.6） months vs. （63.4 ± 7.1） months, and there were statistical differences （P〈0.05）. Conclusions There is a significant correlation between LVI and tumor recurrence and progression in the high-grade pT1 bladder cancer after first TURBT, and the LVI can predict disease progression and poor prognosis.

关 键 词：膀胱肿瘤 复发 随访研究 预后 回顾性研究 

分 类 号：R737.14[医药卫生—肿瘤]