IL-23/Th17在炎症性肠病发病中的作用及治疗意义研究进展  

The Effects of IL-23/Th17 in the Pathogenesis of Inflammatory Bowel Disease and the Research Progress of its Therapeutic Significance

作　　者：朱超慧[1,2] 李楠[1,2] 吴凯[2] 翟俊山[2] ZHU Chaohui LI Nan WU Kai ZHAI Junshan(Postgraduate Team, Medical School of Chinese PLA, Beijing 100039 China Department of Gastroenterology, the 309th Hospital of Chinese PLA, Beijing 100091 China)

机构地区：[1]解放军医学院研究生队,北京100039 [2]解放军309医院消化科,北京100091

出　　处：《辽宁医学院学报》2016年第5期103-106,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：北京市自然基金;项目编号:7132175

摘　　要：IL-23刺激了Th17细胞的分化和增殖,使得Th17细胞分泌IL-17等细胞因子。越来越多的研究资料证实IL-23/Th17细胞炎症轴在炎症性肠病的发病过程发挥重要作用。临床研究显示IL-23和IL-17有望成为炎症性肠病治疗的新靶点。本文结合近年来相关研究及报道针对IL-23/Th17细胞在炎症性肠病发病中的作用及治疗意义做一综述。IL-23 stimulates the differentiation and proliferation of Th17 cells, which makes Th17 cells secrete IL-17 and other cytokines. More and more researches have confirmed that IL-23/Th17 inflammation axis plays an important role in the pathogenesis of inflammatory bowel disease. Clinical researches have showed that IL-23 and IL-17 are expected to become new targets for the treat-ment of inflammatory bowel disease. Combined with related researches and reports in recent years, this article aims to make a review about the effects and therapeutic significance of IL-23/Th17 in the pathogenesis of inflammatory bowel disease.

关 键 词：白细胞介素-23 TH17细胞 白细胞介素-17 炎症性肠病 

分 类 号：R574.6[医药卫生—消化系统]