SWI/SNF染色质重塑在肿瘤中的研究进展  

Research progress of SWI/SNF chromatin remodeling in malignancies

作　　者：张记[1] 吴玉章[1] 阎萍[2] 

机构地区：[1]第三军医大学全军免疫学研究所,重庆400038 [2]第三军医大学西南医院妇产科,重庆400038

出　　处：《基础医学与临床》2016年第10期1437-1440,共4页Basic and Clinical Medicine

基　　金：教育部肿瘤免疫病理学重点实验室开放课题(2012jsz108);长江学者和创新团队发展计划(IRT1052)

摘　　要：染色质重塑复合体SWI/SNF亚基基因在肿瘤中突变率高达20%,突变造成编码蛋白失活及整个复合体功能异常,导致肿瘤发生。目前SWI/SNF抑制肿瘤的已知机制主要包括其与Polycomb复合体间的表观拮抗及与c-Myc及PIK3CA等原癌基因信号通路协同作用等。The mutations of SWI / SNF subunits genes,with high mutation frequence of 20% in human cancers,promote oncogenesis by inactivating the function of encoding proteins and further perturbing the whole function of SWI / SNF complexes. The main mechanism is that SWI / SNF suppresses tumor development include its epigenetic antagonism with Polycomb complexes,as well as synergetic interaction with other oncogene signaling such as c-Myc and PIK3 CA.

关 键 词：SWI/SNF 染色质重塑 ARID1A 

分 类 号：R730.2[医药卫生—肿瘤]