慢性肾病贫血铁治疗与脑铁沉积的研究进展  

The research progress of iron therapy in the treatment of anemia and brain iron deposition in patients with chronic kidney disease

作　　者：刘磊[1,2] 张孟杰[1,2] 柴超[2] 夏爽[2] 

机构地区：[1]天津中医药大学,天津300073 [2]天津市第一中心医院放射科

出　　处：《国际医学放射学杂志》2016年第5期513-517,共5页International Journal of Medical Radiology

基　　金：国家自然科学基金(81501457);天津市卫生行业重点攻关项目(14KG103)

摘　　要：慢性肾病(CKD)已成为全球健康负担且增长迅速。其中,终末期肾病(ESRD)是其发展的最严重阶段。ESRD病人进行血液透析治疗易引发贫血,而使用红细胞生成刺激药物改善贫血的过程中需补充铁剂,但在此过程中存在铁过载风险。铁在脑组织的沉积对脑小血管的损害的研究对于临床制定透析方案有着重要的意义。综述CKD对脑组织功能、结构的影响及MRI技术用于脑铁沉积水平研究的进展。Chronic kidney disease（CKD） is a rapidly growing global health burden, and end-stage renal disease（ESRD） is the most serious stage. Hemodialysis as treatment for final ESRD patients, easily leads to anemia, and the use of Erythropoiesis-Stimulating Agent（ESA） that improves anemia should be added in the iron, but there is a risk of iron overload. The damage of small blood vessels in the brain tissue is still under study, which is important for the clinical development of the dialysis program. This article mainly reviews the effects of chronic kidney disease on the brain function and structure, and the progress of related MRI technology.

关 键 词：慢性肾病 血液透析 贫血 脑铁沉积 磁共振成像 

分 类 号：R743[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]