miRNA调控中心体与肿瘤发生的相关性  

The relationship between miRNA regulating centrosome and tumorgenesis

作　　者：赵凯越 李福才[1] 

机构地区：[1]中国医科大学基础医学院遗传学教研室,辽宁沈阳110122

出　　处：《解剖科学进展》2016年第5期540-542,共3页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81272969)

摘　　要：microRNA(miRNA)是长度为21-25个核苷酸的非编码小RNA,miRNA与靶RNA的3′UTR碱基配对,通过转录后水平对基因表达的负调控,抑制mRNA翻译或直接使其降解。某些miRNA可以通过靶向E2F、cycling、Cdk、CKI等调节因子,调节细胞周期以及中心体的复制,进而影响基因组的稳定性,最终促进或抑制肿瘤的发生。microRNAs （miRNA） is non-coding small RNA in length of 21-25 nucleotides, pairs with its targeting RNA＇ s 3＇UTR, via the negative regulation of the gene expression in posttranseription level to inhibit mRNA＇s translation or directly make it degradation. Some microRNAs can target regulating factors such as E2F, cycling, Cdk, CKI to regulate cell cycle and centrosome replication which affect the stability of the genome, eventually promote or inhibit the occurrence of tumor.

关 键 词：microRNA 细胞周期 原中心粒 靶向 负调控 碱基配对 调控靶基因 基因表达 抑癌基因 肺癌细胞 

分 类 号：R730.2[医药卫生—肿瘤]