DEK蛋白在非小细胞肺癌中的表达及临床意义  

The clinical significance of DEK protein expression in non-small cell lung cancer

作　　者：李景阳 孙丽梅[2] 徐慧慧[2] 惠林平 任洪久 徐艺桐[2] 

机构地区：[1]阜新市第二人民医院病理科,辽宁阜新1230002 [2]中国医科大学基础医学院病理学教研室,辽宁沈阳110122

出　　处：《现代肿瘤医学》2016年第22期3556-3559,共4页Journal of Modern Oncology

基　　金：辽宁省科技厅社会发展攻关计划(编号:2013225021)

摘　　要：目的:探讨DEK蛋白在非小细胞肺癌中的表达及意义。方法:免疫组织化学方法检测DEK蛋白在非小细胞肺癌中的表达情况以及和临床病理因素的相关性。结果:DEK蛋白在非小细胞肺癌中阳性率65.9%。DEK高表达与分化程度呈负相关(r=-0.173,P=0.021);与p TNM分期(r=0.160,P=0.033)和淋巴结转移(r=0.195,P=0.009)呈正相关。DEK高表达的NSCLC患者生存时间低于DEK低表达的NSCLC患者(P=0.021)。结论:DEK是一种癌蛋白,可作为一种新的肿瘤标记物,深入研究DEK可能会为肺癌恶性生物学行为变化提供干预的靶点。Objective： To explore the expression of DEK protein in non- small cell lung cancer and its significance. Methods： We examined the expression of DEK protein and its correlation with clinical pathological factors in non- small cell lung cancer using immunohistochemistry. Results： The positive rate of DEK protein in non- small cell lung cancer was 65. 9%. The high expressions of DEK had negative correlation with the degree of differentiation（ r =- 0. 173,P = 0. 021）,have positive correlation with p TNM stage（ r = 0. 160,P = 0. 033） and lymph node metastasis（ r = 0. 195,P = 0. 009）. Survival time of DEK high expressions in NSCLC patients lower than DEK low expressions in NSCLC patients（ P = 0. 021）. Conclusion： DEK is a oncoprotein,can be used as a new tumor marker,thorough study of DEK may provide intervention targets for malignant behavior change of lung cancer.

关 键 词：DEK 非小细胞肺癌 转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]