纳米人工骨混合自体骨用于骨肿瘤骨切除后填充效果  

Effect of nano-artificial bone mixed with autologous bone for filling after bone tumor resection

作　　者：刘鹏[1] 马敏杰[1] 杨小彬[1] 李涛[1] 

机构地区：[1]西安交通大学医学院附属红会医院,西安710054

出　　处：《现代仪器与医疗》2016年第5期33-36,共4页Modern Instruments & Medical Treatment

摘　　要：目的 :分析人工骨混合自体骨用于骨肿瘤骨切除后填充的临床效果,探讨其临床应用价值。方法 :以我院收治的65例接受骨切除的骨肿瘤患者为研究对象,按照患者填充方式,将接受人工骨混合自体骨填充的患者纳入观察组(n=29),将接受自体骨填充的患者纳入对照组(n=36),比较两组患者植骨量、愈合情况、骨材料降解率,比较其临床效果及安全性。结果 :观察组与对照组平均植骨量为(9.9±1.6)m LVS(7.6±1.8)m L,观察组植骨量稍高于对照组,但组间比较差异无统计学意义(P>0.05);观察组平均愈合时间为(8.9±1.5)个月,对照组平均愈合时间为(8.7±1.6)个月,两组患者植骨愈合时间、愈合情况、骨材料降解率比较,差异无统计学意义(P>0.05);术后均未见伤口感染、不愈合、排异反应等并发症发生;观察组末次随访MSTS评分为(28.71±6.26)分,对照组末次随访MSTS评分为(28.50±6.33)分,组间差异无统计学意义(P>0.05)。结论 :人工骨混合自体骨能够有效填充骨肿瘤骨切除后缺损区域,该方案能够在减少自体骨移植量的基础上保证良好的填充效果及安全性。Objective To analyze the clinical effect of artificial bone mixed with autologous bone for filling after bonetumor resection and to explore its clinical application value. Methods： 65 cases of patients with bone tumor resectionadmitted in our hospital were selected as the research object, according to bone-filling methods, patients who receivedartificial bone mixed with autologous bone filling method were included into the observation group （n=29）, the patientswho received autologous bone graft were included into the control group （n=36）, compared bone graft mass, bonehealing and bone repair material degradation rate between the two groups of patients, and compared their clinical efficacyand safety. Results： The average bone graft mass of the observation group and the control group was （9.9±1.6） mL vs（7.6±1.8） mL, respectively, bone graft mass of the observation group is slightly higher than that of the control group,but there was no significant difference between the two groups （P〉0.05）; the average bone healing time of observationgroup was （8.9±1.5） months, that of control group time was （8.7±1.6） months, bone healing time, healing situation, bonematerial degradation rate were compared between two groups of patients, the difference was not statistically significant（P〉0.05）; there were no postoperative wound infection, nonunion, rejection and other complications in both groups; TheMusculoskeletal Tumor Society （MSTS） score of the observation group at the end of the follow-up was （28.71±6.26）points, and that of the control group was （28.50±6.33） points, there was no significant difference between the two groups（P〉0.05）. Conclusions： Artificial bone mixed with autologous bone can effectively fill the bone defect area after bonetumor resection, which can reduce the autologous bone graft mass and ensure good filling effect and safety.

关 键 词：人工骨 自体骨 骨肿瘤 骨切除 填充 

分 类 号：R738.1[医药卫生—肿瘤]