消栓通络经验汤剂辨治短暂性脑缺血发作(气虚血瘀证)的临床研究  

Research on Treating Transient Ischemic Attack(Qi Deficiency and Blood Resistance Symptoms) Patients with Xiaoshuan Tongluo Decoction

作　　者：陈龙霏 李修壮 王平[1] 罗群[1] 王学工[1] CHEN Longfei Ll Xiuzhuang WANG Ping et al(Rizhao City TCM Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Shandong,Rizhao 276800, China)

机构地区：[1]山东中医药大学附属日照市中医医院,山东日照276800

出　　处：《中国中医急症》2016年第10期1981-1984,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2011-292)

摘　　要：目的观察自拟消栓通络经验汤剂辨治短暂性脑缺血发作(气虚血瘀证)的临床效果。方法将120例患者按随机数字表法分为对照组和治疗组各60例,对照组患者给予硫酸氢氯吡格雷片联合阿司匹林治疗,治疗组患者在对照组基础上联合给予自拟消栓通络经验汤剂内服治疗,两组均连续治疗2周。比较两组临床疗效、治疗前后中医证候积分、凝血功能指标变化、血液流变学指标及平均血流速度变化。结果治疗组的总有效率91.67%,显著高于对照组的76.67%(P<0.05);治疗组治理后中医证候积分明显低于对照组(P<0.05);治疗组患者的凝血功能各指标改善优于对照组患者,PT、APTT水平治疗前后及组间差异无统计学意义(P>0.05),PLT水平显著低于治疗前及对照组(P<0.05);治疗组患者血液流变改善优于对照组(P<0.05);治疗组患者的平均血流速度改善优于于对照组(P<0.05)。结论自拟消栓通络经验汤剂辨治(气虚血瘀证)短暂性脑缺血发作疗效确切,其机制可能与改善脑部血液循环及血流速度、抗血小板作用密切相关,值得临床深入研究探讨。Objective： To investigate the clinical efficacy of Xiaoshuan Tongluo Decoction on transient ischemic attack（syndrome of qi deficiency and blood resistance） patients. Methods： 120 transient ischemic attack patients were randomly divided into control group of 60 cases and treatment group of 60 cases. Patients in the control group were given clopidogrel bisulfate combined aspirin for foundation treatment;while patients in the treatment group were treated with xiaoshuan tongluo decoction, 2 weeks for treatment. The effectiveness and TCM syndrome integrals,the level of blood coagulation function,the improvement of the blood rheological and average blood flow velocity of two groups were compared. Results： The efficiency for patients in the treatment group was 91.67%, which was higher than that of the control group 76.76% （P 〈 0.05）;the symptoms score of treatment group was lower than that of the control group（P〈0.05）;The improvement of the levels of blood coagulation function for the patients in the treatment group was better those of the control group, but the patients＇ levels of PT and APTI＂ had no obvious change before and after treatment （P〉 0.05） ;The level of PLT went down compared with before treat- ment,but the degree of change in the treatment group was more pronounced （P〈 0.05）. The improvement of the blood rheology in patients with the treatment group was better than that in patients with the control group, the dif- ference was significant （P〈 0.05 ）;The average blood flow velocity in patients with the treatment group was better than that of the control group, the difference was significant（P〈 0.05 ）. Conclusion： Treating syndrome of qi defi- ciency and blood resistance transient ischemic attack patients with xiaoshuan tongluo decoction has curative effect. The mechanism is closely related to improve brain blood circulation ,average blood flow velocity and an- tiplatelet effects,is worthy of further research.

关 键 词：短暂性脑缺血发作 气虚血瘀证 消栓通络经验汤剂 中西医结合 

分 类 号：R743.31[医药卫生—神经病学与精神病学]