降血脂药环丙贝特的合成  

Synthesis of Hypolipidemic Ciprofibrate

作　　者：雷继中 赵建强[3] 刘斌 周鸣强[2,3] LEI Ji-zhong ZHAO Jian-qlang LIU Bin ZHOU Ming-qiang(School of Chemical Engineering, Sichuan University, Chengdu 610065, China Chengdu Likai Chiral Tech. Co. , Ltd. , Chengdu 610041, China Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China)

机构地区：[1]四川大学化学工程学院,四川成都610065 [2]成都丽凯手性技术有限公司,四川成都610041 [3]中国科学院成都有机化学研究所,四川成都610041

出　　处：《合成化学》2016年第10期911-913,共3页Chinese Journal of Synthetic Chemistry

基　　金：中国科学院西部之光青年学者项目

摘　　要：报道了一种合成降血脂药物环丙贝特的新工艺。以对羟基苯甲醛为原料,经Witting反应、醚化、环化及水解共4步反应合成了环丙贝特,总收率69.4%,纯度99.7%,其结构经1H NMR,13C NMR和HR-MS(ESI)确证。A new approach for the synthesis of hypolipidemic ciprofibrate was reported. Ciprofibrate with an overall yield of 69.4% and purity up to 99.7% was obtained via Witting reaction, etherification, cyclization and hydrolysis using 4-hydroxybenzaldehyde as the starting material. The structure was confirmed by 1H NMR, 13C NMR and HR-MS（ESI）.

关 键 词：对羟基苯甲醛 降血脂药 环丙贝特 Witting反应 药物合成 

分 类 号：P014.5[天文地球] O621.3[理学—有机化学]