盐酸多奈哌齐开环杂质的合成  

Synthesis of Donepezil Hydrochloride Ring-opening Impurity

作　　者：柴雨柱 王足兵 李志华 吴晶 徐丹 朱春霞 CHAI Yu-zhu WANG Zu-bing LI Zhi-hua WU Jing XU Dan ZHU Chun-xia(Nanjing Chia Tai Tianqing Co. , Ltd. , Nangjing 210038, China)

机构地区：[1]南京正大天晴制药有限公司,江苏南京210038

出　　处：《合成化学》2016年第10期914-916,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以盐酸多奈哌齐为起始原料,与草酸二乙酯和双氧水经一锅煮法合成了多奈哌齐的开环杂质,纯度98.8%,总收率31.2%,其结构经1H NMR和MS(ESI)确证。The Donepezil hydrochloride ring-opening impurity with the yield of 31.2% and purity of 98.8% was synthesized by a one-pot reaction of Donepezil hydrochloride with diethyl oxalate and hy- drogen peroxide. The structure was confirmed by 1H NMR and MS（ESI）.

关 键 词：盐酸多奈哌齐 草酸二乙酯 双氧水 开环杂质 合成 

分 类 号：R914.5[医药卫生—药物化学] O621.3[医药卫生—药学]