化疗所致的特殊皮肤改变:病例报道及文献复习  

Specific skin changes caused by chemotherapy : cases report and literature review

作　　者：丁林[1,2] 李青剑 汪颖[3] 柴洁[3] 江志敏[1,2] 姚和瑞[1,2,3] 

机构地区：[1]广东省恶性肿瘤表观遗传学和基因调控重点实验室,广州510120 [2]中山大学孙逸仙纪念医院肿瘤科,广州510120 [3]中山大学孙逸仙纪念医院乳腺肿瘤医学部,广州510120

出　　处：《岭南现代临床外科》2016年第5期564-569,共6页Lingnan Modern Clinics in Surgery

基　　金：国家自然科学基金(81372819;81572596);教育部博士点基金(20120171110075);中山大学青年教育重点培育项目(13ykzd14);广州市科技计划(2014J4100170)

摘　　要：目前中国居民的首位病死原因仍是癌症,其发病率和死亡率逐年升高,化疗是癌症患者主要的全身治疗手段。皮肤毒性则是化疗常见的副作用之一,由于化疗后的皮肤毒性发生不容易危及生命,所以常被忽视,但却常常影响患者的生活质量,甚至导致药物减量和治疗的中断,最终影响化疗疗效。现将我科诊治的4例化疗药物所致罕见的皮肤改变报道如下并作相关文献复习。Cancer has remained to be the first cause to death for Chinese residents, with its incidence and mortality increasing year by year. Chemotherapy is the main systemic therapy for cancer patients, which frequently causes skin toxicity. This side effect hardly poses threats to lives, thus often neglected. However, skin toxicity usually influences the quality of life and leads to the decrease or pause of chemical drugs, which harms the curative effect. Hereby we report four rare skin changes led by chemotherapy in our department and review the relevant articles.

关 键 词：化疗 皮肤 副作用 

分 类 号：R730.53[医药卫生—肿瘤]