基于静息态功能连接的杏仁核谱聚类研究  

Study on spectral clustering of amygdala using resting state functional connectivity

作　　者：田洪君 高全胜[2] 高军峰[3,4] 窦顺阳 

机构地区：[1]深圳市贝斯达医疗股份有限公司,深圳518172 [2]解放军军事医学科学院实验动物中心,北京100850 [3]中南民族大学认知科学国家民委重点实验室,武汉430074 [4]电子科技大学生命科学与技术学院,成都610054 [5]西安交通大学生命科学与技术学院,西安710049

出　　处：《磁共振成像》2016年第10期769-774,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81271659;81171385);中国博士后科学基金资助(编号:2014M552346)~~

摘　　要：目的研究根据全脑各体素的功能连接模式的相似性,以谱聚类的方式对杏仁核脑区进行分割的可行性。材料与方法通过静息态功能成像,根据特定脑区内各体素全脑功能连接模式的相似性,以谱聚类对杏仁核脑区进行分割。结果右侧中央内侧核(centromedial,CM)亚区分割结果与图谱最接近,右侧浅表核(superficial,SF)脑区亚区与谱图相似度较低。聚类组的稳定性分析结果显示在信噪比大于70 db的情况下,各子区都保持了近乎与没有加入噪声的结果100%的相似性,在10 db的低信噪比下各区皮尔森相关系数也能保持0.7左右。结论本研究的聚类结果和julich图谱具有高度一致性,表明这一方法在可行性、稳定性和抗干扰性方面也取得了满意结果,相对于传统手动分割方法,本研究的聚类方法简单、高效、可重复性高。Objective： According to the similarity of the functional connectivity pattern of the whole brain, the feasibility of using spectral clustering to segment the brain regions of the amygdala was studied. Materials and Methods： By resting state functional imaging according to the functional connectivity pattern of each voxel in a specific brain region, spectral clustering was performed to segment the amygdala region. Results： The segmentation results of subregion on the right side of the central medial nucleus （CM） were similar to that of the map, and the results of subregion on the right superficial nuclei （SF） were relatively less similar to the spectra. Cluster analysis results of the stability analysis results showed that the signal-to-noise ratio was more than 70 db, each subregion maintained 100% similarity to the results without adding noise, the pearson correlation coefficient could be kept about 0.7 in the low signal-to-noise ratio of 10 db. Conclusion： The clustering results and JULICH maps were highly consistent, which indicated the feasibility of this method. In addition, satisfactory results were also obtained in terms of stability and anti-interference. Compared with the traditional manual segmentation method, the clustering segmentation method proposed in this paper had the advantages of simplicity, high efficiency, and high repeatability.

关 键 词：杏仁核 磁共振成像 功能连接 谱聚类 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338.2[医药卫生—诊断学]