结合型胆汁酸对胆管癌的诊断价值  

The value of analysis on conjugated bile acids in biliary tract cancer

作　　者：王文娟 郑丹[2] 刘彬[3] 

机构地区：[1]成都市妇女儿童中心医院检验科,四川成都610014 [2]广汉市人民医院检验科,四川广汉618300 [3]广汉市人民医院肝胆科,四川广汉618300

出　　处：《遵义医学院学报》2016年第4期403-405,409,共4页Journal of Zunyi Medical University

摘　　要：目的探讨胆汁酸代谢的改变对胆管癌的诊断价值。方法采用反向高效液相色谱紫外检测法(RP-HPLCUV)分别测定15例胆管癌患者、38例胆结石患者以及21例无胆道疾病的腹部外伤患者胆汁中9种结合型胆汁酸浓度。结果胆管癌组胆汁中甘氨胆酸(GCA)和甘氨鹅脱氧胆酸(GDCA)明显高于胆结石组和对照组(P<0.05);胆结石组胆汁中牛磺胆酸(TCA)、牛磺脱氧胆酸(TDCA)高于胆管癌组和对照组(PP<0.05)。结论胆汁中结合型胆汁酸谱可作为潜在的生物学指标来早期诊断胆管癌。Objective To explore the possibel value of change on metabolism of bile acid in diagnosis of biliary tract cancer. Methods 15 biliary tract cancer patients,38 gallstone patients and 21 normal controls were randomly enrolled. The concentrations of nine conjugated bile acids in bile were determined by RP- HPLC- UV.Results The proportion of GCA and GCDCA were increased in biliary tract cancer group than that in biliary tract stone group（ P〈 0. 05）. The proportion of TCA and TDCA were increased in biliary tract stone group than that in both biliary tract cancer and control groups（ P〈 0. 05）. Conclusion Conjugated bile acids might be the potential biomarkers for the early diagnosis of biliary tract cancer.

关 键 词：胆管癌 胆汁 胆汁酸 色谱法 

分 类 号：R735.8[医药卫生—肿瘤]