恶性梗阻性黄疸双介入治疗的临床效果  

Clinical effect of double interventional radiology therapy in malignant obstructive jaundice

作　　者：李海渊[1] 周芳[1] 张状[1] 纪艳兵 于佳丽[1] 

机构地区：[1]秦皇岛市第二医院医学影像科,河北秦皇岛066600

出　　处：《热带医学杂志》2016年第9期1129-1131,1167,共4页Journal of Tropical Medicine

基　　金：秦皇岛市市级科技计划项目(201401A256)

摘　　要：目的探讨经皮经肝胆道引流术联合动脉化疗灌注治疗恶性梗阻性黄疸患者临床效果。方法选择2011年1月至2014年1月秦皇岛市第二医院收治的恶性梗阻性黄疸患者83例,依据随机数字表法随机分为观察组(n=42)与对照组(n=41)。对照组采用经皮经肝胆道引流术治疗,观察组在对照组基础上联合动脉化疗灌注治疗。比较死亡情况和术后1周总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、白蛋白(ALB)变化,术后并发症及术后死亡情况和生存时间。结果两组血清TBIL、DBIL、ALT、ALB水平术后1周明显下降(P<0.05);观察组血清TBIL、DBIL、ALT、ALB水平治疗后低于对照组(P<0.05);两组并发症发生率比较差异无统计学意义(P>0.05);两组术后死亡率比较差异无统计学意义(P>0.05);观察组平均生存时间明显长于对照组,差异有统计学意义(P<0.05)。结论经皮经肝胆道引流术联合动脉化疗灌注治疗恶性梗阻性黄疸患者临床效果明显,可明显延长患者生存时间。Objective To evaluate percutaneous biliary drainage combined with arterial infusion chemotherapy in the treatment of malignant obstructive jaundice. Methods 83 cases of malignant obstructive jaundice selected from period January 2011-January 2014 in our hospital were randomly divided into observe group（n =42） and control group（n =41）.The control group received percutaneous biliary drainage treatment, while the observation group was treated with percutaneous biliary drainage combined with arterial infusion chemotherapy treatment. The preoperative and postoperative1 week total bilirubin（TBIL）, direct bilirubin（DBIL）, alanine aminotransferase（ALT）, albumin（ALB） change,postoperative complications and postoperative mortality and survival time were compared. Results The serum levels of TBIL, DBIL, ALT and ALB of both groups after 1 week were significantly decreased（P〈0.05）.The serum levels of TBIL, DBIL, ALT and ALB of the observed group were significantly lower than those of the control group（P〈0.05）;there was no significant difference in the incidence of complications between the two groups（P〉0.05）; no significant difference in postoperative mortality（P〉0.05）. In the observe group, the average survival time was significantly longer than that of the control group（P〈0.05）. Conclusion The percutaneous biliary drainage combined with arterial infusion chemotherapy in the treatment of malignant obstructive jaundice has significant clinical effect, and can significantly prolong the survival time of patients.

关 键 词：经皮经肝胆道引流术 动脉化疗灌注 恶性梗阻性黄疸 

分 类 号：R575[医药卫生—消化系统]