469例结直肠癌术后患者预后因素分析  

The analysis of prognostic factors in 469 cases of colorectal cancer

作　　者：邓建良[1] 王维民[1] 顾贤成[1] 汤月华[1] 张国强[1] 周炎[1] 

机构地区：[1]江苏大学附属宜兴医院肿瘤科,江苏宜兴214200

出　　处：《热带医学杂志》2016年第9期1171-1173,共3页Journal of Tropical Medicine

基　　金：无锡市科技局医疗与公众健康技术研发项目(CSE31N1333);江苏省恶性肿瘤生物标志物与防治重点实验室开放课题(11ZLKF09)

摘　　要：目的探讨影响结直肠癌术后患者预后的因素。方法回顾性分析469例结直肠癌患者的临床病理及生存随访资料。采用Cox回归模型分析性别、年龄、肿瘤直径大小、浸润深度、分化程度、淋巴结转移情况、TNM分期、癌胚抗原(CEA)、糖类抗原(CA125、CA199)与预后的关系。结果性别、年龄、肿瘤直径大小与结直肠癌术后患者预后均无关(P>0.05);分化程度、浸润深度、淋巴结转移、TNM分期、CEA、CA-125均与结直肠癌术后患者预后密切相关,且差异有统计学意义(P<0.01)。结论分化程度、浸润深度、淋巴结转移、TNM分期、CEA、CA-125均可作为结直肠癌术后患者预后的主要危险因素之一。Objective To explore the prognostic factors in colorectal cancer patients. Methods 469 colorectal cancer patients who were treated by surgery in Yixing Hospital Affiliated to Jiangsu University from January 2006 to December2010 were collected through retrospective analysis.The relationship between gender, age, tumor diameter, depth of invasion,differentiation, lymph node metastasis,TNM stage, CEA, CA125, CA199 and prognosis by Cox regression analysis. Results Gender, age, tumor diameter were not related with prognosis（P〉0.05）,but the depth of invasion, differentiation, lymph node metastasis,TNM stage, CEA and CA125 were related with prognosis（P〈0.01）. Conclusion Depth of invasion,differentiation, lymph node metastasis,TNM stage, CEA and CA125 were independent and effective indicators of prognosis in colorectal cancer patients.

关 键 词：结直肠癌 病理分期 影响因素 

分 类 号：R735.3[医药卫生—肿瘤]