牙周炎合并冠心病患者血清新喋呤水平的研究  

The study of serum neopterin levels in patients with periodontal disease and coronary heart disease

作　　者：任静[1] 陈珊[1] 代静[1] 陈燕斌[1] 周倩冰[1] 杨军英[1] 

机构地区：[1]中山大学附属第一医院口腔科,广州510080

出　　处：《中华口腔医学研究杂志（电子版）》2016年第4期272-276,共5页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：中山大学国家级大学生创新训练项目(201310558091)

摘　　要：目的探讨慢性牙周炎与冠心病患者血清中新喋呤水平的变化及相关关系。方法选取受检者共120例,分为4组,每组30例:牙周炎合并冠心病组(C+P)、单纯牙周炎组(P)、单纯冠心病组(C)和健康对照组(H)。记录性别、年龄等一般统计学资料。检查牙周指标,包括全口牙齿的数量、探诊深度(PD)、临床附着丧失(CAL)和探诊出血,同时检测血清新喋呤和血脂水平。采用ANOVA法分析以上指标在各组间的差异,Pearson法分析血清各指标与牙周指标间的相关性。结果各组间牙周指标差异有统计学意义(P<0.05)。(C+P)组的血清新喋呤显著高于P组、C组和H组,差异有统计学意义(P<0.05)。P组、C组的血清新喋呤又显著高于H组,差异有统计学意义(P<0.05)。受检者的血清新喋呤水平与PD、CAL呈正相关。结论牙周炎与冠心病存在一定的关系,新喋呤可能与二者的病理机制相关。Objective To explore the possible relationship of serum neopterin levels with chronic periodontitis and coronary heart disease（CHD）. Methods A total of 120 patients were recruited in this study,including 30 patients with periodontitis and coronary heart disease （C＋P）,30 patients with periodontitis（P）,30 patients with coronary heart disease（C）,30 healthy controls（H）. All parameters, including age,gender and periodontal clinic index,were recorded. Serum neopterin levels and lipid levels were examined at the same time. Differences in parameters among the four groups were analyzed by ANOVA. Correlations of each serum parameters with periodontal indexes were analyzed by Pearson correlation. Results The periodontal indexes were significantly different among the four groups （P〈0.05）. In（C＋P）group,serum neopterin levels were significantly higher than that of P,C and H groups （P〈0.05）. The serum neopterin levels of P and C groups were significantly higher than that of H group （P〈0.05）. Serum neopterin levels were significantly correlated to probing depth and clinical attachment loss. Conclusions A certain correlation might exist between periodontitis and CHD,and neopterin might be closely related with the pathogenesis of these two diseases.

关 键 词：牙周炎 冠心病 新喋呤 临床附着丧失 炎症 

分 类 号：R781.42[医药卫生—口腔医学] R541.4[医药卫生—临床医学]