高血糖对肝癌患者外科治疗后复发影响的研究  

Clinical investigation of hyperglycemia and postoperative recurrence of hepatocellular carcinoma

作　　者：刘溪涛[1] 仝林虎[1] 陈加明[1] 乌星 

机构地区：[1]内蒙古医科大学附属医院肝胆胰腺外科,010059

出　　处：《中华普外科手术学杂志（电子版）》2016年第5期426-428,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

摘　　要：目的研究高血糖对肝癌患者外科治疗后复发的影响。方法回顾性分析2012年4月到2014年5月期间进行肝癌外科手术治疗的患者86例,其中40例高血糖(≥6.1 mol/L)患者作为高血糖组,46例血糖正常患者作为正常组,采用SPSS 19.0软件进行统计学的处理。24个月无瘤生存率采用卡方检验;空腹血糖用x珋±s表示,t检验。对参与本次研究的相关因素进行Kaplan-Meier的比例风险检验,多因素分析进行Log-rank分析,P<0.05差异具有统计学意义。结果对86例患者24个月无瘤生存率进行单因素的分析,结果表明患者术中输血量>200 ml,空腹血糖≥6.1 mmol/L,术后AFP>8.1μg/L能够大幅度的提高患者复发率,多因素结果显示,这3个指标是影响肝癌术后无瘤生存率的相关独立危险因素,差异均有统计学意义(P<0.05)。结论高血糖与肝癌患者外科治疗后复发有着密切的关联,高血糖可以提高肝癌患者复发率,临床上对患者血糖进行监控有利于预防患者肝癌患者复发,具有积极意义。Objective To investigate the impact of hyperglycemia on the postoperative recurrence of hepatocellular carcinoma. Method From April 2012 to May 2014,clinical data of 86 patients underwent hepatectomy were analyzed retrospectively,including 40 cases of hyperglycemia（ ≥ 6. 1 mol / L） in high blood glucose group and 46 cases of normal blood glucose in normal group. Statistical analysis were performed by using SPSS 19. 0 software. 24-Months disease free survival was examined by chi square test.Fasting blood-glucose were presented as x^-± s and examined by using t test. Related risk factors were examined by using Kaplan Meier proportional hazards test and multi-factor analysis were performed by using log-rank analysis. A P value of 〈0. 05 was considered as significant difference. Results Single factor analysis of 24-Months disease free survival was performed in 86 patients,which showed that intraoperative blood transfusion 〉200 ml,fasting blood-glucose ≥6. 1 mmol / L and postoperative AFP 〉8. 1 μg / L might significantly increase postoperative recurrence. Multivariate results showed that above three indicators independent risk factor of are impact-free survival after hepatectomy,with significant difference（ P〈0. 05）.Conclusion There is a close correlation of hyperglycemia and postoperative recurrence of hepatocellular carcinoma. Monitoring and controlling of blood glucose of patients might help to prevent the recurrence of hepatocellular carcinoma,which is of positive clinical significance.

关 键 词：肝肿瘤 高血糖症 肿瘤复发 局部 

分 类 号：R735.7[医药卫生—肿瘤]