食管癌患者根治性放疗前、后机体免疫功能状态对比分析  

Comparison of the Body Immunity Function of Esophagus Cancer Patients before and after Radical Radiation Therapy

作　　者：张莉莉[1] 于荣桓 吴侠[1] 

机构地区：[1]山东省邹城市兖矿集团总医院,273500

出　　处：《实用癌症杂志》2016年第10期1719-1721,共3页The Practical Journal of Cancer

摘　　要：目的对比食管癌患者根治性放疗前、后患者机体免疫功能状态。方法选取行根治性放疗的62例食管癌患者为研究对象(研究组),所有病例均经病理检查确诊,并接受根治性放疗。选择同期进行健康体检的30例健康者作为对照组。62例患者于根治性放疗前1周及放疗结束后1个月进行样本采集。对比食管癌患者放疗前的体液免疫、细胞免疫水平与正常对照组间的差异,并对其放疗前后的免疫球蛋白含量与T细胞各亚群及NK细胞比例进行对比。结果患者放疗前血清lgG、lgM及lg A水平与正常对照组比较无显著性差异(P>0.05);放疗后各免疫球蛋白水平均较放疗前有降低趋势,但经统计分析差异未见显著性(P<0.05)。食管癌患者放疗前CD4+细胞比例低于正常对照组(P<0.05),放疗后CD4+细胞比例较放疗前进一步下降(P<0.05);放疗前食管癌患者CD8+细胞比例显著高于正常对照组(P<0.05),放疗后较放疗前有所降低(P<0.05);食管癌组CD4+/CD8+比值在放疗前显著低于正常对照组(P<0.05),放疗后较放疗前显著升高(P<0.05)。研究组放疗前NK细胞比例显著低于正常对照组(P<0.05),放疗后较放疗前进一步下降,差异具有显著性(P<0.05)。结论根治性治疗会下调细胞免疫效应水平,造成机体免疫功能紊乱,因此在进行放疗时宜适当应用增强免疫功能类药物,延长化疗间隔,对于提高患者生存率具有重要意义。Objective To compare the body immunity function of esophagus cancer patients before and after radical radiation therapy.Methods 62 esophagus cancer patients were selected.Through the pathological examination,the patients adopted the radical radiation therapy.30 healthy check-ups were selected as the control group.The specimen 1 week before and 1 month after treatment were collected.Before treatment,the humoral immunity and cellular immunity of the 2 groups were compared; before and after treatment,the ratio of immune globulin content with T cell subsets and NK cells were compared.Results Before treatment,the level of lg G,lg M and lg A of the 2 groups was not significantly different（P〉0.05）; after treatment,the immune globulin content was slightly lower（P〈0.05）; before treatment,the ratio of CD4 ＋ for esophagus cancer group was lower than the control group（P〈0.05）; after treatment,the ratio of CD4 ＋ was lower（P〈0.05）; before treatment,the ratio of CD8 ＋ for esophagus cancer group was significantly higher than the control group（P〈0.05）; after treatment,the ratio of CD8 ＋ was lower（P〈0.05）.The ratio of CD4 ＋ and CD8 of esophagus cancer group was significantly lower than control group（P〈0.05）; after treatment,the ratio was higher（P〈0.05）.Before treatment,the ratio of NK of esophagus cancer group was significantly lower than the control group（P〈0.05）; after treatment,the ratio was lower（P〈0.05）.Conclusion Radical radiation therapy can regulate the immune response and cause immunity function disorders.Therefore,it is proper to take drugs enhancing the immune function and extend the intervals of therapy.It is of great importance to improve survival rate of patients.

关 键 词：食管癌 根治性放疗 免疫 

分 类 号：R735.1[医药卫生—肿瘤]